{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:47:16Z","timestamp":1787755636044,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":325,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18411965100"],"award-info":[{"award-number":["18411965100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR2041B"],"award-info":[{"award-number":["SHDC2020CR2041B"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12023116"],"award-info":[{"award-number":["SHDC12023116"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> To describe the clinical patterns and visual outcomes of pediatric uveitis at a tertiary referral center in East China.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Retrospective case series. Clinical records of patients with pediatric uveitis who presented between January 2014 and July 2021 were reviewed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The children included (<jats:italic>n<\/jats:italic>\u2009=\u2009283; 146 females, 137 males) had a mean age at presentation of 10.6\u2009\u00b1\u20093.5\u2009years. There was a predominance of chronic (62.9%), noninfectious (81.3%) disease, and anterior uveitis was the most common uveitis type (54.8%). Idiopathic chronic anterior uveitis (17.3%) and juvenile idiopathic arthritis (JIA)\u2013associated anterior uveitis (16.3%) were the most common noninfectious types; ocular toxocariasis (14.8%) and viral retinitis (1.4%) were the most common infectious etiologies. Ocular complications were observed in 53.0% of patients during follow\u2010up. Systemic immunosuppressive therapy was administered to 66.8% of patients, 67.2% of whom required immunosuppressive drugs and\/or biological agents (127\/189 children). Surgical treatment was conducted in 38 (13.4%) patients. Improvement or preservation of visual acuity was observed in 95.2% of patients for whom follow\u2010up visual acuity was recorded (179\/188 patients).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Pediatric uveitis was predominantly chronic and noninfectious, with anterior involvement. Systemic therapy was required by most patients, and most eyes showed improved visual acuity.<\/jats:p>","DOI":"10.1155\/joph\/5015614","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T09:49:49Z","timestamp":1732182589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pediatric Uveitis in a Tertiary Referral Center in East China: Clinical Patterns and Visual Outcomes"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-8663","authenticated-orcid":false,"given":"Boya","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3742-4512","authenticated-orcid":false,"given":"Ruiping","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinmeng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-2515","authenticated-orcid":false,"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-8980","authenticated-orcid":false,"given":"Qing","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8441-9690","authenticated-orcid":false,"given":"Gezhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7760-0598","authenticated-orcid":false,"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2021.06.006"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2016.1239745"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14535"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(03)00314-3"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.002"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.06.014"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2017.1420202"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-308194"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273940802702561"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.044"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2016.1160129"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2015.1012298"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1766083"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.01.053"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02838.x"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-1971-2"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(01)00925-4"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70075-3"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.11.020"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(98)93028-7"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.12.024"},{"key":"e_1_2_11_23_2","first-page":"390","article-title":"International League of Associations for Rheumatology Classification of Juvenile Idiopathic Arthritis: Second Revision, Edmonton, 2001","volume":"31","author":"Petty R. 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