{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:42:20Z","timestamp":1777869740718,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":119,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Amyloidosis involves the deposition of fibrillar proteins in tissues. Hereditary transthyretin amyloidosis (ATTRv), caused by TTR gene mutations, affects various tissues, with ocular involvement in about 10% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe and quantify ocular manifestations in ATTRv through a systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed studies on ocular manifestations of ATTRv, including only articles in Portuguese and English, excluding case reports, conference abstracts, and duplicates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen studies with 1792 patients were analyzed. Vitreous opacities were found in 87.5% of studies (36% frequency). Dry eye was reported in 50% (48.5% frequency) and scalloped pupil in 37.5% (35.9% frequency). Glaucoma had an average frequency of 18.2%, while amyloid deposits in the lens appeared in 37.5% of studies (25.8% frequency). Retinal hemorrhage and vascular tortuosity were less common, and conjunctival lymphangiectasia was found in one study (54.2%). The Val30Met mutation was most prevalent, noted in 92% of cases. No clear link between ocular and systemic symptoms was identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitreous opacities were the most common ocular manifestation, followed by dry eye and scalloped pupil. Further research is needed due to the limited number of representative studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joph\/5277348","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:32:43Z","timestamp":1777559563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ophthalmological Manifestations of Hereditary Amyloidosis due to Transthyretin: A Systematic Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-0557","authenticated-orcid":false,"given":"Maria 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