{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:05:42Z","timestamp":1784271942217,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":196,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["4951-10-07"],"award-info":[{"award-number":["4951-10-07"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311811\/2022-1"],"award-info":[{"award-number":["311811\/2022-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare peripapillary retinal nerve fiber layer (pRNFL), choroidal microvascular dropout (CMvD) and vessel density (pVD), as well as macular ganglion cell complex (GCC) and vessel density (mVD) in eyes with glaucoma and optic neuritis (ON) due to multiple sclerosis (MS\u2010ON) or neuromyelitis optica spectrum disorder (NMOSD\u2010ON) using OCT and OCT angiography (OCTA), and to assess its correlations with visual acuity and visual field (VF) parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010one eyes (16 patients) with glaucomatous optic neuropathy (GON), 26 eyes (16 patients) with MS\u2010ON, 19 eyes (12 patients) with NMOSD\u2010ON, and 53 healthy eyes (27 subjects) underwent 24\u20102 VF, OCT, and OCTA. The pRNFL thickness, pVD, and CMvD, as well as macular GCC thickness and mVD, were analyzed and compared using generalized estimating equations. Area under the receiver operating characteristic curves was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All disease groups showed significantly reduced structural parameters compared to controls. MS\u2010ON and NMOSD\u2010ON did not differ and demonstrated greater GCC thinning than GON despite similar pRNFL thickness (except nasally). mVD did not significantly differ among disease groups. In contrast, superficial and deep pVD distinguished the disease groups from controls and were significantly lower in nasal and temporal sectors in MS\u2010ON and particularly in NMOSD\u2010ON compared to GON. Although CMvD occurred in all groups, it was significantly more frequent and extensive in GON. Significant correlations were found between OCTA and OCT and visual function parameters in MS\u2010ON and NMOSD\u2010ON but not in GON eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OCT and OCTA parameters seem to differentiate GON, MS\u2010ON, and NMOSD\u2010ON from controls, but substantial overlap exists among the diseases. The presence of CMvD, particularly when extensive, was more commonly observed in GON, although its presence in other groups limits its diagnostic specificity.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Brazilian Clinical Trials Registry: 76722517.2.0000.0068\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joph\/6354194","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:46:01Z","timestamp":1784270761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of OCT Structural Parameters and OCTA\u2010Measured Retinal Vessel Density and Peripapillary Choroidal Microvasculature in Glaucoma and Optic Neuritis From Multiple Sclerosis or Neuromyelitis Optica"],"prefix":"10.1155","volume":"2026","author":[{"given":"Glauco Batista","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Am\u00e9rico","family":"Domingos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-3652","authenticated-orcid":false,"given":"Marcelo","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-3315","authenticated-orcid":false,"given":"Leandro Cabral","family":"Zacharias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-1790","authenticated-orcid":false,"given":"Leonardo Provetti","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8347-2393","authenticated-orcid":false,"given":"Luiz Guilherme Marchesi","family":"Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-2791","authenticated-orcid":false,"given":"M\u00e1rio Luiz Ribeiro","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-01288-x"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/icu.0000000000000955"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-100419-111350"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0564-2"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.08.008"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28280"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/con.0000000000000768"},{"key":"e_1_2_9_8_2","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1038\/s41433-024-02995-5","article-title":"Global Estimates on the Number of People Blind or Visually Impaired by Glaucoma: A Meta-Analysis From 2000 to 2020","volume":"38","author":"Study V. 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