{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:53:24Z","timestamp":1782118404547,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":172,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Our purpose is to report the results of a prospective study on ocular discomfort and objective tear film parameters (osmolarity and NIKBUT), in myopic patients, and observe the possible differences at 1\u2009month between randomized groups in the use of topical lubricants 1\u2009week prior to surgery or just after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective, single masked, randomized, comparative study. Refractive error and UDVA, BCVA, tear osmolarity, OSDI test, and keratograph analysis of the tear film were performed per patient by a masked examiner before and 1\u2009day, 1\u2009week, and 1\u2009month after FS\u2010LASIK performed to correct myopia in both pre and post groups. A total of 22 patients per group were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age was 32.27\u2009\u00b1\u20095.4 and 32.85\u2009\u00b1\u20095.3\u2009years, and mean preop sphere was \u22123.17\u2009\u00b1\u20092.3 and 2.75\u2009\u00b1\u20091.3 D in pre and post groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). In addition, no statistically significant difference was found in preoperative OSDI, tear osmolarity, or NIKBUT between both groups. In the whole cohort, the OSDI worsened significantly from a preop value of 6.94\u2009\u00b1\u20097.15 to a value of 15.66\u2009\u00b1\u200912.55 at 1\u2010month postop (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                    <jats:p>We did not find any statistically significant differences in the OSDI score, NIKBUT, or osmolarity at the 1\u2010month postop between the pre and post groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Femto\u2010LASIK increased OSDI at 1\u2009month. One\u2010week pretreatment with hyaluronate\u2013HP\u2010guar did not improve symptoms, osmolarity, or NIKBUT compared with postoperative use only. More trials with longer follow\u2010up are needed.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Spanish Agency of Medicines and Medical Devices (AEMPS): Code 25\u20100055\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joph\/6643075","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:40:46Z","timestamp":1782117646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a One\u2010Week Lubricant Pretreatment on Post\u2010LASIK Dry Eye: Single\u2010Center Randomized, Single\u2010Masked Study With 1\u2010Month Follow\u2010Up"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-0297","authenticated-orcid":false,"given":"Rafael","family":"Ca\u00f1ones-Zafra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Allendes-Urquiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mu\u00f1iz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-9882","authenticated-orcid":false,"given":"Miguel A.","family":"Teus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/opx.0b013e31829d9905"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1057685"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s421369"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.61004"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.ijo_3406_22"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.001"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.356"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s4475"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00847-1"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s259704"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147512"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2016.12.019"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597x-20070601-11"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4903831"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2020.4931"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/joph\/6643075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/joph\/6643075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/joph\/6643075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:40:47Z","timestamp":1782117647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/joph\/6643075"}},"subtitle":[],"editor":[{"given":"Qinxiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/joph\/6643075"],"URL":"https:\/\/doi.org\/10.1155\/joph\/6643075","archive":["Portico"],"relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6643075"}}