{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:34:30Z","timestamp":1793406870042,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To evaluate the performance of the anterior segment optical coherence tomography (AS\u2010OCT) and Scheimpflug\u2013Placido tomographic (SPT) indices in differentiating suspect keratoconus (SKC) from normal (N).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    In this cross\u2010sectional study, one eye of each patient was scanned on AS\u2010OCT and SPT. Following, 5 regression analysis models were developed: Model 1: combined AS\u2010OCT corneal thickness (CT); Model 2: combined AS\u2010OCT epithelial thickness (ET); Model 3: Models 1\u2009+\u20092; Model 4: SPT indices (symmetry index front [SIf], symmetry index back [SIb], keratoconus vertex back [KVb], and minimum CT [ThkMin]); Model 5: Models 3\u2009+\u20094. The areas under the curve (AUC) of receiver operator characteristic (ROC) curves were compared across groups to estimate their performance accuracy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Two hundred and five\u2009N eyes, 56 SKC eyes, and 89 keratoconus (KC) eyes were scanned with AS\u2010OCT and SPT. For Models 1 and 2, no individual metric yielded an AUC &gt; 0.84. For Model 3, the AUC was 0.96 (R2 Nagelkerke: 0.69) with 90.28% cases correctly identified as SKC. For Model 4, the AUC was 0.99 (R2 Nagelkerke: 0.87), with 95.58% of cases correctly classified as SKC. For Model 5, the diagnostic accuracy did not improve compared to Model 4.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Both combined AS\u2010OCT indices and combined SPT indices provided excellent diagnostic power to differentiate SKC from N eyes. The combined SPT model showed a superior value compared to the AS\u2010OCT model. Furthermore, combined AS\u2010OCT and SPT data did not perform better than the combined SPT data alone.\n                  <\/jats:p>","DOI":"10.1155\/joph\/6647993","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:08:01Z","timestamp":1742342881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Combined Utilization of Epithelial Thickness and Tomographic Parameters in Keratoconus 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