{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:46:50Z","timestamp":1792072010176,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":287,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Retinal vein occlusion (RVO) is a common retinal vascular disorder associated with systemic vascular and metabolic risk factors. Although both dyslipidemia and inflammation have been implicated in its pathogenesis, the associations of conventional lipid parameters, derived atherogenic indices, and hemogram\u2010derived inflammatory markers with RVO remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, single\u2010center, case\u2013control study included 81 patients with RVO and 91 controls without RVO. Hospital records from January 2025 through December 2025 were reviewed. Conventional lipid parameters, derived atherogenic indices, and systemic inflammatory markers were compared between groups. Multivariable logistic regression analyses were performed using separate models for conventional lipid parameters, derived lipid indices, and inflammatory indices to reduce collinearity and improve interpretability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with RVO were older than controls and had significantly higher monocyte, neutrophil, and leukocyte counts, as well as higher C\u2010reactive protein (CRP), low\u2010density lipoprotein cholesterol (LDL\u2010C), triglyceride, total cholesterol, and non\u2013high\u2010density lipoprotein cholesterol (non\u2010HDL\u2010C) levels. Among the derived indices, total cholesterol\/high\u2010density lipoprotein cholesterol (HDL\u2010C), LDL\u2010C\/HDL\u2010C, and non\u2010HDL\u2010C\/HDL\u2010C ratios were significantly higher in the RVO group, whereas neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), neutrophil\u2010to\u2010platelet ratio (NTR), hemoglobin\u2010albumin\u2010lymphocyte\u2010platelet (HALP) score, systemic immune\u2010inflammation index (SII), and triglyceride\/HDL\u2010C ratio were comparable between groups. In models adjusted for age, sex, and CRP, LDL\u2010C, non\u2010HDL\u2010C, and total cholesterol were associated with RVO, whereas triglyceride was not. Total cholesterol\/HDL\u2010C, LDL\u2010C\/HDL\u2010C, and non\u2010HDL\u2010C\/HDL\u2010C ratios were also associated with RVO in models adjusted for age, sex, and CRP, whereas triglyceride\/HDL\u2010C was not. None of the evaluated inflammatory indices was associated with RVO in models adjusted for age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this dataset, several cholesterol\u2010related variables were associated with RVO in models adjusted for age, sex, and CRP, whereas none of the evaluated hemogram\u2010derived inflammatory indices was associated with RVO in models adjusted for age and sex. Because these variables were examined in separate models with different covariate adjustments, the findings do not establish the superiority or greater relative importance of lipid markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joph\/6862613","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:02:42Z","timestamp":1792069362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Lipid Profile, Atherogenic Indices, and Systemic Inflammatory Markers in Retinal Vein Occlusion: A Retrospective Case\u2013Control Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-5294","authenticated-orcid":false,"given":"Nurcan","family":"G\u00fcrsoy","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Of State Hospital  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6567-8467","authenticated-orcid":false,"given":"\u015eenay","family":"Deniz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ku\u015fadas\u0131 State Hospital  Ayd\u0131n T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13133950"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)31559-2"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03909.x"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111850"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143080"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02562-3"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000036512"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263587"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28367"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14955"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010075"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095089"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2023.117312"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16335"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz413"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197413"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2018.287037"},{"key":"e_1_2_13_18_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanepe.2023.100774","article-title":"Non-HDL Cholesterol and Residual Risk of Cardiovascular Events in Patients With Ischemic Heart Disease and Well-Controlled LDL Cholesterol: A Cohort Study","volume":"36","author":"Hansen M. 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