{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:47:17Z","timestamp":1782550037973,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":177,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine complete blood count parameters for differences in chronic dacryocystitis compared to controls, exploring their potential link to a possible allergic\u2010inflammatory contribution in lacrimal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 190 adults aged 18\u201383\u2009years who underwent external dacryocystorhinostomy (DCR) for primary acquired nasolacrimal duct obstruction (PANDO) with chronic dacryocystitis between January 2018 and June 2023. Preoperative peripheral blood samples were analyzed for leukocyte, neutrophil, platelet, eosinophil, and monocyte counts. Neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), neutrophil\u2010to\u2010monocyte ratio (NMR), monocyte\u2010to\u2010lymphocyte ratio (MLR), and neutrophil\u2010to\u2010eosinophil ratio (NER) were calculated and compared with a control group consisting of age\u2010 and sex\u2010matched healthy individuals who underwent routine ophthalmological examinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eosinophil counts were significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) and NER significantly lower (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014) in the DCR group compared to controls, with no significant differences in other parameters (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated eosinophil levels and reduced NER suggest a possible allergic\u2010inflammatory contribution to chronic dacryocystitis. NER may serve as a potential biomarker for identifying patients with an allergic\u2010inflammatory profile; however, prospective studies are required to establish its clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joph\/8447280","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:33:03Z","timestamp":1782549183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced Neutrophil\u2010to\u2010Eosinophil Ratio in Chronic Dacryocystitis: A Hematological Clue to Allergic Pathogenesis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-9753","authenticated-orcid":false,"given":"Gokhan","family":"Ozgur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-5699","authenticated-orcid":false,"given":"Konuralp","family":"Yakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6058-4226","authenticated-orcid":false,"given":"Onur","family":"Gokmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120672119854582"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/ojo.ojo_116_23"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omab009"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s200923"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.06.009"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02191-5"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02090-6"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02391-z"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13091342"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.58600\/eurjther.20232902-1574.y"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-03262-3"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)96015-8"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3393"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1515\/rjr-2017-0018"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/iop.0000000000002599"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090720"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.09.007"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000357004"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103127"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-024-00416-y"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/children10071207"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23660"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.797473"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2016.1424"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/iop.0000000000001310"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0b013e31825bd2cb"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.308"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2012.723110"},{"key":"e_1_2_14_29_2","first-page":"1","article-title":"A Study to Compare the Relationship Between Tissue Eosinophilia and Radiological Findings in Nasal Polyposis","volume":"76","author":"Gupta D. 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