{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:03:15Z","timestamp":1777903395665,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":126,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["JSPH-MC-2021-18"],"award-info":[{"award-number":["JSPH-MC-2021-18"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["QG202405"],"award-info":[{"award-number":["QG202405"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    In clinical practice, some eyes preoperatively diagnosed with \u201cidiopathic epiretinal membranes (iERM)\u201d will be amended to \u201csecondary epiretinal membranes (sERM)\u201d once peripheral retinal hole is detected. This study utilized optical coherence tomography (OCT) images to compare the characteristics between the iERM and sERM due to peripheral retinal hole (PRH).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    In this retrospective, cross\u2010sectional study, 635 eyes that had undergone pars plana vitrectomy with membrane peeling were enrolled. A total of 115 eyes (18.1%) detected with peripheral retinal holes were allocated to the sERM\u2010PRH group while the other 520 eyes were to the iERM group. The demographic data and OCT characteristics were compared between the two groups. Besides, all the eyes were evaluated by a double\u2010grading scheme: severity grading of ERM progression into four stages plus anatomical classification into three kinds of part\u2010thickness macular holes associated with ERMs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    No significant difference was found in age, gender, symptom duration, axial length, or best\u2010corrected visual acuity between the two groups. There was also no difference concerning the features based on OCT, ranging from central macular thickness, the ratios of the photoreceptor inner\/outer segment junction line defect, intraretinal fluid, cotton ball sign, to epiretinal proliferation. However, the native difference in parafoveal thickness between the temporal and nasal quadrants was observed in the iERM group, yet disappeared in the sERM\u2010PRH group. Moreover, eyes between the two groups were distributionally similar in both grading scales.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Our results demonstrated that even OCT images could hardly provide effective clues for early differentiating sERM from iERM, which highlighted the necessity of a thorough pre\u2010 and intro\u2010operative fundus examination of the peripheral retina for clinicians.\n                  <\/jats:p>","DOI":"10.1155\/joph\/9299651","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T01:48:39Z","timestamp":1746668919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optical Coherence Tomography Characteristics Between Idiopathic Epiretinal Membranes and Secondary Epiretinal Membranes due to Peripheral Retinal Hole"],"prefix":"10.1155","volume":"2025","author":[{"given":"Yuanyuan","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxia","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-8970","authenticated-orcid":false,"given":"Ping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-1964","authenticated-orcid":false,"given":"Qinghuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-8937","authenticated-orcid":false,"given":"Lijun","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-1804","authenticated-orcid":false,"given":"Zizhong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000000349"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.101833"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014644"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13914"},{"key":"e_1_2_10_5_2","first-page":"91","article-title":"A Review of Last Decade Developments on Epiretinal Membrane Pathogenesis","volume":"9","author":"Tsotridou E.","year":"2020","journal-title":"Medical Hypothesis, Discovery & Innovation Ophthalmology Journal"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-7116"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0b013e3181ef8786"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-014-0010-1"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.79"},{"key":"e_1_2_10_10_2","first-page":"161","article-title":"The Impact of Optical Coherence Tomography on Surgical Decision Making in Epiretinal Membrane and Vitreomacular Traction","volume":"104","author":"Do D. 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