{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:19:46Z","timestamp":1790270386908,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":228,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003841","name":"Ilam University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003841","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    \u200b Understanding the immune pathogenesis mechanisms of leishmaniasis is crucial for developing effective therapeutic interventions. In this study, we investigated the effect of ivermectin (IVE) on the expression of transcription factors GATA\u2010binding protein 3 (GATA\u20103), T\u2010bet, and ROR\u2010\u03b3t as well as wound healing Leishmania infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Leishmania promastigotes were subcutaneously inoculated into the tail base of BALB\/c mice (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910 per group) who later received phosphate\u2010buffered saline (PBS), IVE, Glucantime, or a combination of IVE and Glucantime as soon as wounds developed, approximately three weeks\u2019 postinfection. The treatment continued daily for 2\u2009weeks. The diameter of the wound was measured weekly over 6\u2009weeks. In addition, in the sixth week, the mRNA expression of T\u2010bet, GATA\u20103, and ROR\u2010\u03b3t in splenic T cells was assessed through real\u2010time PCR analysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The findings of this research indicated a significant reduction in the lesion size among the treated groups compared with the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). IVE had a similar effect to Glucantime in reducing wound diameter (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). Furthermore, the combined use of Glucantime and IVE led to the most reduction in the lesion size among all groups. The treated groups exhibited higher expression levels of T\u2010bet and ROR\u2010\u03b3t and lower levels of GATA\u20103 compared with the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    IVE has shown significant efficacy in accelerating the healing process of wounds related to leishmaniasis. In addition, the administration of this medication has triggered a strong immune response, marked by activation of T helper 1 (Th1) and Th17\u2009cells while also modulating Th2 responses.\n                  <\/jats:p>","DOI":"10.1155\/jotm\/5579789","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T04:09:35Z","timestamp":1755490175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Ivermectin on Immune Response and Wound Healing in a Mouse Model Infected With\n                    <i>Leishmania major<\/i>"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5029-4383","authenticated-orcid":false,"given":"Abdolbaset","family":"Rahmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-6598","authenticated-orcid":false,"given":"Nahid","family":"Maspi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9593-3003","authenticated-orcid":false,"given":"Hamid","family":"Hasanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-2168","authenticated-orcid":false,"given":"Shahab","family":"Falahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5766-0120","authenticated-orcid":false,"given":"Tooran","family":"Nayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-9083","authenticated-orcid":false,"given":"Razi","family":"Naserifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/0972060x.2013.764177"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2016.1232042"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-007-8012-y"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.4110\/in.2024.24.e14"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00248-22"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/653829"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1023381027062"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103336"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050329"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1645\/ge-185r"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2019.1610887"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.10-0171"},{"key":"e_1_2_14_13_2","first-page":"1","article-title":"Serological Evaluation of EgAgB16 Kda, a Recombinant Antigen From Echinococcus granulosus for Diagnosis of Human Hydatidosis","volume":"5","author":"Abdi J.","year":"2010","journal-title":"Iranian Journal of Parasitology"},{"key":"e_1_2_14_14_2","first-page":"175","article-title":"Comparison Between the Efficacy of Ivermectin and Other Drugs in Treatment of Cutaneous Leishmaniasis","volume":"23","author":"Kadir M.","year":"2009","journal-title":"Iraqi Journal of Veterinary Sciences"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.12.003"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2020.108059"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2020-0090"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156143"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2015.1123604"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.03.013"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261570598"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.105262"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2012.11.003"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-007-0638-0"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b01451"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-020-02612-z"},{"key":"e_1_2_14_28_2","first-page":"207","article-title":"Efficacy of Ivermectin on the Infectivity of Leishmania major Promastigotes","volume":"28","author":"Rasheid K. 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