{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:05:41Z","timestamp":1785157541784,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":207,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005288","name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brazil has implemented multiple policies targeting congenital syphilis (CS); however, evaluations of their effectiveness remain limited. This study aimed to analyze temporal trends in annual rates of gestational syphilis (GS) and CS from 2011 to 2022 across Brazil and its regions. It was hypothesized that effective prenatal care would enable early GS detection and that appropriate treatment of pregnant patients and their partners would reduce CS detection rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This temporal study used GS and CS notification data from all Brazilian municipalities. National and regional annual rates were analyzed using the joinpoint regression model. Annual percent change (APC), average APC (AAPC), 95% confidence intervals, and\n                      <jats:italic>p<\/jats:italic>\n                      values were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 586,855 new GS cases and 272,491 CS cases were reported during the study period. GS rates increased throughout Brazil and all regions, accompanied by a decline in APC values. For CS, rates achieved overall stabilization in Brazil as well as the North, Midwest, and South regions, whereas the Southeast and Northeast regions experienced continuous growth with a reduced APC from 2015 and 2017, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although CS trends stabilized or increased at reduced APC values over time, rates remain high. Additional efforts are required to eliminate the disease, including earlier initiation of prenatal care and improved prevention, diagnosis, and treatment of syphilis in pregnant patients and their partners.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jotm\/6589431","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:37:45Z","timestamp":1785155865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successes and Challenges in the Elimination of Congenital Syphilis in Brazil: Evidence of Progress and Persistent Challenges"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0204-232X","authenticated-orcid":false,"given":"Iaron Leal","family":"Seabra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0924-3221","authenticated-orcid":false,"given":"Nyla Lauane Costa de","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3523-3451","authenticated-orcid":false,"given":"Bianca Rafaele Souza","family":"Trindade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6524-6953","authenticated-orcid":false,"given":"Arthur da Silva Costa","family":"Pedroza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-6503","authenticated-orcid":false,"given":"Thayse Moraes de","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-4950","authenticated-orcid":false,"given":"Glenda Roberta Oliveira Naiff","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-6530","authenticated-orcid":false,"given":"Eli\u00e3 Pinheiro","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"Sustainable Health Agenda for the Americas 2018-2030: A Call to Action for Health and Well-Being in the Region [Internet]","author":"Pan American Health Organization","year":"2017"},{"key":"e_1_2_10_2_2","unstructured":"Organiza\u00e7\u00e3o Pan-Americana da Sa\u00fade (OPAS) Greater Efforts Needed to Accelerate the Elimination of Syphilis and Congenital Syphilis in the Americas [Internet]. Washington D.C.: OPAS 2023 https:\/\/www.paho.org\/en\/news\/12-5-2023-greater-efforts-needed-accelerate-elimination-syphilis-and-congenital-syphilis."},{"key":"e_1_2_10_3_2","volume-title":"Mother-To-Child Transmission of Syphilis","author":"World Health Organization","year":"2024"},{"key":"e_1_2_10_4_2","volume-title":"Transforming Our World: The 2030 Agenda for Sustainable Development","author":"World Health Organization","year":"2015"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-611-2020"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/S2237-96222023000300003.EN"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027118"},{"key":"e_1_2_10_8_2","article-title":"Departamento De HIV\/Aids, Tuberculose, Hepatites Virais e Infec\u00e7\u00f5es Sexualmente Transmiss\u00edveis","author":"Brasil Minist\u00e9rio da Sa\u00fade. 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Departamento de Doen\u00e7as de Condi\u00e7\u00f5es Cr\u00f4nicas e Infec\u00e7\u00f5es Sexualmente Transmiss\u00edveis","author":"Brasil Minist\u00e9rio da Sa\u00fade","year":"2021","journal-title":"Agenda de a\u00e7\u00f5es Estrat\u00e9gicas Para Redu\u00e7\u00e3o Da S\u00edfilis No Brasil 2020-2021"},{"key":"e_1_2_10_13_2","article-title":"Secretaria de Aten\u00e7\u00e3o Prim\u00e1ria \u00e0 Sa\u00fade. Departamento de Gest\u00e3o do Cuidado Integral","author":"Brasil Minist\u00e9rio da Sa\u00fade","year":"2023","journal-title":"Guia do Pr\u00e9-Natal do Parceiro Para Profissionais de Sa\u00fade"},{"key":"e_1_2_10_14_2","unstructured":"Conselho Nacional de Secret\u00e1rios de Sa\u00fade (Conass) Minist\u00e9rio da Sa\u00fade Lan\u00e7a A\u00e7\u00e3o Nacional de Combate \u00e0 S\u00edfilis [Internet]. 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