{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:28:44Z","timestamp":1790724524187,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Dengue is one of the major public health concerns in tropical and subtropical countries. In addition to neurological sequelae which are well documented, emerging evidence suggests that dengue may also lead to psychiatric sequelae including mood disorders, psychosis, anxiety, and body dysmorphic disorder. This narrative review aims to synthesize the existing literature to explore the psychiatric manifestations and postulated pathophysiological mechanisms and identify predictors and treatment of psychiatric sequelae in dengue. This review identified 30 studies including observational studies, case reports, and case series. The immune\u2010inflammatory responses due to cytokine dysregulation, blood\u2013brain barrier disruption, direct viral effects, and epigenetic mechanisms with histone deacetylase activation are possible contributors to psychiatric sequelae in dengue. The main predictors include severity of dengue, thrombocytopenia, central nervous system involvement, febrile and critical phase of illness, specific dengue virus serotypes (DENV\u20102 and DENV\u20103), and stress due to hospitalization. Psychiatric symptoms often persist beyond the acute phase, highlighting the importance of long\u2010term follow\u2010up to evaluate the impact of dengue on mental health. Additionally, comparisons with other Flaviviridae viruses, such as Zika, West Nile, and Japanese encephalitis viruses, reveal both shared and distinct psychiatric implications, suggesting potential virus\u2010specific mechanisms. The current treatment approaches are largely extrapolated from general psychiatric practice, with limited research on targeted interventions. Future research should focus on standardized diagnostic assessment, longitudinal follow\u2010up, diagnostic biomarkers, and developing targeted treatment strategies to improve clinical outcomes. With rising cases of dengue, integrating psychiatric screening into routine dengue management may enhance early recognition and intervention. Hence, a multidisciplinary research approach involving psychiatrists, neurologists, infectious disease specialists, immunologists, and policymakers is crucial for addressing psychiatric sequelae in dengue fever and mitigating the detrimental implications on public health.<\/jats:p>","DOI":"10.1155\/jotm\/7136558","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T03:25:08Z","timestamp":1748229908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Psychiatric Sequelae of Dengue: A Review of the Interface"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-0911","authenticated-orcid":false,"given":"Priyanka Renita","family":"D\u2019Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-1662","authenticated-orcid":false,"given":"Debora Sona","family":"D\u2019Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2017.57"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.63.5"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.5.2817"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2014.09.011"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(13)70150-9"},{"key":"e_1_2_10_6_2","first-page":"101","article-title":"A Clinical Study to See the Psychological Effects of Dengue Fever","volume":"5","author":"Gill K. U.","year":"2011","journal-title":"Pakistan Journal of Medical & Health Sciences"},{"key":"e_1_2_10_7_2","first-page":"239","article-title":"Anxiety and Depression in Patients of Dengue Fever","volume":"3","author":"Khan M. A.","year":"2012","journal-title":"Rawal Medical Journal"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.2190\/pm.44.3.b"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777x.122021"},{"key":"e_1_2_10_10_2","first-page":"62","article-title":"Depression, Anxiety, Stress and Their Effect upon the Self-Efficacy in Dengue Patients","volume":"30","author":"Mushtaq M.","year":"2016","journal-title":"JPMI: Journal of Postgraduate Medical Institute"},{"key":"e_1_2_10_11_2","article-title":"A Study on Post-Dengue Depression","volume":"60","author":"Ali S.","year":"2017","journal-title":"Depression"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13033-018-0202-6"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.17098\/amj.435269"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17010099"},{"key":"e_1_2_10_15_2","first-page":"740","article-title":"Psychological Health and People Perceptions About Dengue","volume":"13","author":"Rashid S.","year":"2019","journal-title":"Pakistan Journal of Medical & Health Sciences"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5680229"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.10075"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taae081"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0012239"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.22764"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-6748.98418"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.13189\/iid.2014.020101"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2013.11.002"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.4103\/psychiatry.IndianJPsychiatry_311_18"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12948"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2020.08.001"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47425"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-010-0029-9"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.13110350"},{"key":"e_1_2_10_30_2","first-page":"58","article-title":"Post Dengue Psychosis","volume":"1","author":"Kar S.","year":"2013","journal-title":"Indian Journal of Biological Psychiatry"},{"key":"e_1_2_10_31_2","first-page":"119","article-title":"A Case of Psychotic Disorder Due to Dengue Fever","volume":"18","author":"Abdullah M. F.","year":"2017","journal-title":"ASEAN Journal of Psychiatry"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-2870.202104"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.3126\/jnps.v37i3.16481"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.55628"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.4088\/pcc.22cr03241"},{"key":"e_1_2_10_36_2","volume-title":"World Health Organization: Department of Control of Neglected Tropical Diseases, World Health Organization: Epidemic, Pandemic Alert. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control","author":"WHO-TDR","year":"2009"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-282x2011000700014"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-024-01030-9"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_66_17"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1590\/0101-60830000000206"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1086\/506939"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.4088\/pcc.22cr03379"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.06.001"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.02.020"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003488.pub3"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2011.12.007"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10121626"}],"container-title":["Journal of Tropical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jotm\/7136558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jotm\/7136558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jotm\/7136558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:57:06Z","timestamp":1777636626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jotm\/7136558"}},"subtitle":[],"editor":[{"given":"Rajib","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/jotm\/7136558"],"URL":"https:\/\/doi.org\/10.1155\/jotm\/7136558","archive":["Portico"],"relation":{},"ISSN":["1687-9686","1687-9694"],"issn-type":[{"value":"1687-9686","type":"print"},{"value":"1687-9694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7136558"}}