{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:47:11Z","timestamp":1787399231462,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pregnancy"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Preeclampsia is correlated with an inflammatory condition. Necroptosis is a programmed cell death with an inflammatory state. Vitamin D has anti\u2010inflammatory properties; however, there has been no study linking vitamin D and necroptosis in preeclampsia. This study is aimed at evaluating vitamin D status and necroptosis activity in preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted in Jakarta during 2021\u20132023. Subjects were grouped into normal and preeclampsia. Following delivery, venous blood and placental samples were taken. Serum and placental 25(OH)D assays were performed by LC\u2010MS\/MS. Immunohistochemistry was performed to measure necrosomes RIPK1, RIPK3, and MLKL in trophoblast and endothelial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 60 subjects participated (31 normal and 29 preeclampsia). The preeclampsia group had lower gestational age (35 vs. 38 weeks), lower birth weight (3080.33 \u00b1 454.62\u2009g vs. 2283.27 \u00b1 833.63\u2009g), lower placental weight (580.40 \u00b1 129.36\u2009g vs. 453.06 \u00b1 173.65\u2009g), lower placental 25(OH)D (15.00 [3.50\u201358.00] vs. 26.50 [5.00\u2013153.00] ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014), and higher trophoblast RIPK3 (93.88 [23.94] vs. 76.20 [20.59],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). A mild to moderate negative correlation between placental 25(OH)D and trophoblast RIPK3 (\u22120.352,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003), endothelial RIPK3 (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.244,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), and trophoblast MLKL (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.296,\n                      <jats:italic>r<\/jats:italic>\n                      \u2212 0.011) were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower placental 25(OH)D concentration is associated with an increased placental necroptosis activity in preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jp\/4106792","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:30:47Z","timestamp":1774963847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Protective Effect of Vitamin D Against Necroptosis in Preeclampsia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4531-2924","authenticated-orcid":false,"given":"Atikah Sayogo","family":"Putri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-6273","authenticated-orcid":false,"given":"Rima","family":"Irwinda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-6870","authenticated-orcid":false,"given":"Noroyono","family":"Wibowo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"Profil Kesehatan Indonesia Tahun 2018","author":"Kementerian Kesehatan Republik Indonesia","year":"2018"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-024-06687-6"},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/AOG.0000000000003892","article-title":"ACOG Practice Bulletin Summary, Number 222","volume":"135","author":"Gestational Hypertension and Preeclampsia","year":"2020","journal-title":"Obstetrics and gynecology"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.014"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.94848"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.10.012"},{"key":"e_1_2_10_7_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.13181\/mji.v26i2.1617","article-title":"Assessment of the Nutrient Intake and Micronutrient Status in the First Trimester of Pregnant Women in Jakarta","volume":"26","author":"Wibowo N.","year":"2017","journal-title":"Medical Journal of Indonesia"},{"key":"e_1_2_10_8_2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/10641955.2016.1190846","article-title":"Preeclampsia and Preterm Delivery: A Population-Based Case-Control Study","volume":"35","author":"Davies E. 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