{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:13:42Z","timestamp":1783674822246,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":190,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pregnancy"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Gestational diabetes mellitus (GDM) is associated with metabolic and inflammatory alterations that may influence melatonin metabolism. This study evaluated associations between dietary intake of tryptophan\u2010rich foods, urinary 6\u2010sulfatoxymelatonin, and serum tumor necrosis factor\u2010alpha (TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ) levels in pregnant women with GDM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study included 34 women with GDM and 18 with normal\u2010risk pregnancies. Dietary habits were assessed using a validated food frequency questionnaire (FFQ). Serum TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      and first\u2010morning urinary 6\u2010sulfatoxymelatonin levels were measured by ELISA. Associations were evaluated using generalized linear models (GLMs), adjusting for maternal age, body mass index (BMI), gestational age, and sleep quality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women with GDM reported a significantly higher frequency of consumption of tryptophan\u2010rich foods, particularly milk and dairy products (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01) and fruits (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The GDM group also exhibited higher urinary 6\u2010sulfatoxymelatonin (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) and serum TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      levels (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.023). In multivariable models, GDM remained significantly associated with higher urinary 6\u2010sulfatoxymelatonin levels, whereas TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      concentrations were primarily associated with maternal characteristics and interaction effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      GDM was associated with higher urinary 6\u2010sulfatoxymelatonin and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      levels despite greater reported intake of tryptophan\u2010rich foods. These findings highlight associations between dietary precursors, melatonin metabolism, and inflammatory markers in hyperglycemic pregnancy and underscore the need for longitudinal studies to clarify underlying mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jp\/4762066","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:18:37Z","timestamp":1783671517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnant Women With Gestational Diabetes Mellitus and High Consumption of Tryptophan\u2010Rich Foods Show Increased Levels of 6\u2010Sulfatoxymelatonin in Urine"],"prefix":"10.1155","volume":"2026","author":[{"given":"Daiane Bonella","family":"Coltro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"de Oliveira Mateus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"de Oliveira Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia In\u00eas","family":"Goettert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Costella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-6622","authenticated-orcid":false,"given":"Guilherme Liberato","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraci L. 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