{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:43:29Z","timestamp":1777103009581,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":114,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012286","name":"Deputy for Research and Technology, Kermanshah University of Medical Sciences","doi-asserted-by":"publisher","award":["4040410"],"award-info":[{"award-number":["4040410"]}],"id":[{"id":"10.13039\/501100012286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pregnancy"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Genital herpes (Herpes Simplex Virus Type 2) infection (HSV\u20102 IgG) is a common infection in adults. Given that the virus can indirectly affect fetal development, the infection is particularly important in pregnant women. The disease can remain latent for extended periods and, in addition to causing chronic and recurrent complications, can sometimes result in miscarriage. This study is aimed at investigating the global seroprevalence, risk factors, and outcomes of HSV\u20102 IgG during pregnancy through a systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In this study, the electronic databases, including PubMed, Scopus, Web of Science, Embase, ScienceDirect, and Google Scholar, were systematically searched to find studies reporting the seroprevalence of HSV\u20102 IgG until February 2025. A random\u2010effects model was used for analysis. Heterogeneity between studies was assessed using the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      index. Data analysis was performed using the software Comprehensive Meta\u2010Analysis (Version 2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the analysis of 15 studies with a sample size of 19,197 pregnant women, the global seroprevalence of HSV\u20102 IgG in pregnant women was reported as 23.4%. In examining the factors influencing the heterogeneity of the studies and the impact of sample size on this heterogeneity, it was reported that as sample size increased, the seroprevalence of HSV\u20102 IgG in pregnant women decreased (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Additionally, the findings suggested that with the increase in the year of study, the seroprevalence decreased (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In this study, a history of sexually transmitted diseases and having more than one sexual partner were also identified as factors associated with HSV\u20102 IgG in pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given the seroprevalence (HSV\u20102 IgG), associated factors, and significant complications of contracting this infection during pregnancy, it is recommended that relevant authorities provide the necessary resources to increase awareness among the public and apply appropriate prevention and follow\u2010up measures to minimize the risk of infection.<\/jats:p>\n                  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