{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:59:22Z","timestamp":1790589562901,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":270,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Skin Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real\u2010world evidence on immune checkpoint inhibitors (ICIs) in Latin American patients with melanoma remains limited, particularly for acral and mucosal subtypes. We evaluated survival, radiologic response, immune\u2010related adverse events (irAEs), and exploratory factors associated with outcomes in a Colombian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective cohort included consecutive patients with histologically confirmed melanoma who received\u2009\u2265\u20091 ICI dose between February 2017 and November 2022. Patients were classified as adjuvant\u2010 or palliative\u2010intent. rwOS and irAEs were assessed in the overall cohort; rwDFS in the adjuvant\u2010intent cohort; and rwPFS and best radiologic response in the palliative\u2010intent cohort. Survival was estimated using Kaplan\u2013Meier methods, with median follow\u2010up calculated by reverse Kaplan\u2013Meier. Primary Cox proportional hazards analyses of rwPFS and rwOS were restricted to the palliative\u2010intent cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010seven patients were included: 20 received adjuvant\u2010 and 37 palliative\u2010intent therapy. Median age was 65\u2009years (IQR, 54\u201376); acral and mucosal melanoma accounted for 26 (45.6%) and 11 (19.3%) cases, respectively. Median follow\u2010up was 32.3\u2009months (95% CI, 25.9\u201342.3). In the adjuvant\u2010intent cohort, median rwDFS and rwOS were 23.3\u2009months (95% CI, 4.8\u2013not reached) and 33.0\u2009months (95% CI, 30.1\u2013not reached), respectively. In the palliative\u2010intent cohort, median rwPFS and rwOS were 8.5\u2009months (95% CI, 6.0\u201324.1) and 26.0\u2009months (95% CI, 17.9\u2013not reached), respectively. Among 31 response\u2010evaluable patients, ORR was 38.7% (95% CI, 23.7\u201356.2) and DCR was 54.8% (95% CI, 37.8\u201370.8). IrAEs were documented in 31 patients (54.4%); five had Grade 3 events, and no Grade 4 or five irAEs were documented. In adjusted models, ECOG performance status and melanoma subtype were not significantly associated with rwPFS or rwOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ICIs demonstrated antitumor activity in this Colombian real\u2010world cohort, including patients with acral and mucosal melanoma, although survival estimates were numerically lower than those reported in selected pivotal trials. Documented toxicity was predominantly low grade. Exploratory analyses suggested more favorable outcomes in patients with conventional cutaneous melanoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jskc\/3904810","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:43:03Z","timestamp":1790588583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Outcomes of Immune Checkpoint Inhibitors in Melanoma, Including Acral and Mucosal Subtypes: A Retrospective Cohort Study From a Latin American Center"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-6883","authenticated-orcid":false,"given":"Vaneza","family":"Avila-Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-9894","authenticated-orcid":false,"given":"Juan 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