{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:05:42Z","timestamp":1780031142948,"version":"3.53.1"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":147,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005969","name":"Universit\u00e0 di Bologna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Skin Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous lymphomas (CLs) are rare neoplastic skin disorders, primarily of T\u2010cell origin. Since the widespread rollout of SARS\u2010CoV\u20102 vaccines, several cases of CLs and non\u2010neoplastic lymphoproliferative disorders (nn\u2010LPDs) temporally associated with vaccination have been reported, raising concerns about a potential immunologic link.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review the literature on cases of CLs and related nn\u2010LPDs occurring after COVID\u201019 vaccination, focusing on clinical features, subtype distribution, latency to onset, and proposed pathophysiological mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted according to PRISMA guidelines. Case reports and series describing new\u2010onset or relapsed CLs or nn\u2010LPDs temporally following SARS\u2010CoV\u20102 vaccination were included. Demographic, clinical, histological, therapeutic and temporal data were extracted and analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen manuscripts encompassing 35 cases met the inclusion criteria. Eighteen (51.4%) were histologically confirmed CLs, most commonly lymphomatoid papulosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), followed by S\u00e9zary syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093) and mycosis fungoides (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092). The remaining 17 cases (48.6%) were classified as nn\u2010LPDs, including cutaneous lymphoid hyperplasia, lymphomatoid reactions and CD4+ small\/medium T\u2010cell lymphoproliferative disorders. CD30 positivity was noted in 76.2% of the cases with available immunophenotyping. Most patients (80%) received the BNT162b2 (Pfizer\u2013BioNTech) vaccine. In the 17 new\u2010onset CLs, time to onset ranged from 3 to 42\u2009days, with most cases clustering within 14\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most of the cases were low\u2010grade T\u2010cell CLs and nn\u2010LPDs. Although a causal relationship cannot be established, the short latency observed in many new\u2010onset cases raises the possibility that some patients may have harboured an undiagnosed disease, with vaccination acting as a trigger for clinical manifestation or for raised awareness. These findings support indeed the need for continued pharmacovigilance among clinicians, especially in patients with prior or latent lymphoproliferative conditions. Nevertheless, these extremely rare and indolent events should not alter the overall favourable risk\u2013benefit profile of COVID\u201019 vaccination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jskc\/4893577","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:55:48Z","timestamp":1780030548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Lymphomas and Lymphoproliferative Disorders Associated With SARS\u2010CoV\u20102 Vaccination: A Systematic Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-6112","authenticated-orcid":false,"given":"Martina","family":"Mussi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3323-9216","authenticated-orcid":false,"given":"Corrado","family":"Zengarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-4998","authenticated-orcid":false,"given":"Alberto","family":"Corr\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6318-2739","authenticated-orcid":false,"given":"Tullio","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3984-4708","authenticated-orcid":false,"given":"Alessio","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-3350","authenticated-orcid":false,"given":"Michelangelo","family":"La Placa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-9689","authenticated-orcid":false,"given":"Bianca Maria","family":"Piraccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-409X","authenticated-orcid":false,"given":"Alba","family":"Guglielmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-7171","authenticated-orcid":false,"given":"Alessandro","family":"Pileri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2022.104126"},{"key":"e_1_2_10_2_2","doi-asserted-by":"crossref","unstructured":"CuiZ.andChengJ. 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