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Although traditionally associated with toxicity, recent research highlights their diverse biological activities, including anti\u2010inflammatory, anticancer, antimicrobial, and neuroprotective effects. These properties arise from their ability to interact with cell membranes, modulate key signaling pathways, and influence immune responses. Selected GAs, such as solasonine, solamargine, and \u03b1\u2010tomatine, have demonstrated the potential to regulate inflammation, induce apoptosis in cancer cells, affect the tumor microenvironment, and modulate microglial activity in the nervous system. Moreover, their toxicity remains an important limitation, emphasizing the need for further studies on structure\u2013activity relationships and strategies to reduce adverse effects while preserving therapeutic potential. 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