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Cadmium (Cd) is a nonessential and highly toxic heavy metal with a prolonged biological half\u2010life and extensive environmental persistence, posing substantial risks to the ecosystem and human health. Exposure to cadmium is linked to nephrotoxicity, carcinogenicity, endocrine disruption, and reproductive issues. This review critically evaluates the emerging role of graphene\u2010based nanoparticles, particularly graphene oxide (GO) and its functional derivatives, in reducing Cd bioavailability in soil, wastewater, and along the food chain. GO\u2010based composites can achieve adsorption capacities above approximately 50\u2013500\u2009mg cadmium per gram of material, depending on functionalization and matrix, highlighting their substantial removal potential. Recent evidence demonstrates graphene\u2019s dual functionality: as a potent adsorbent for cadmium ions and as an enhancer of biological tolerance to cadmium\u2010induced toxicity in both plants and human cells. To our knowledge, this review is the first to comprehensively integrate cross\u2010disciplinary evidence on (i) the integration of engineered graphene membranes for selective filtration under pressure, (ii) GO\u2010enhanced soil amendments that reduce cadmium uptake, (iii) thiol\u2010functionalized composites for precise metal adsorption, and (iv) magnetic graphene nanoparticles enabling suitable cadmium removal. By integrating cross\u2010disciplinary evidence, we provide a comprehensive roadmap for implementing graphene nanoenabled environmental interventions. Despite promising outcomes, most available evidence is based on laboratory\u2010scale studies, with limited field\u2010scale validation and an incomplete understanding of the long\u2010term environmental fate and ecotoxicity of graphene nanomaterials.<\/jats:p>","DOI":"10.1155\/jt\/7838711","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:32:48Z","timestamp":1771223568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Potential of Graphene Nanoparticles for Reducing Cadmium Toxicity and Environmental Contamination"],"prefix":"10.1155","volume":"2026","author":[{"given":"Alireza Ghassemi","family":"Toussi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Einafshar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0096-0153","authenticated-orcid":false,"given":"Sadaf Sadat","family":"Rafati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14010094"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04170-3"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/402647"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/tqem.70193"},{"key":"e_1_2_15_5_2","volume-title":"Biotreatment of Industrial Effluents","author":"Doble M.","year":"2005"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2022-0096"},{"key":"e_1_2_15_7_2","first-page":"307","volume-title":"Food Safety and Preservation","author":"Mohammad A.-M.","year":"2018"},{"key":"e_1_2_15_8_2","doi-asserted-by":"crossref","DOI":"10.1201\/b12786","volume-title":"Soils and Environmental Quality","author":"Pierzynski G. 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