{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:50:45Z","timestamp":1791291045163,"version":"4.3.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":278,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Toxicology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Despite its traditional use in Africa for weight management, the safety profile of the aqueous stem bark extract of\n                      <jats:italic>Stereospermum acuminatissimum<\/jats:italic>\n                      remains undocumented. This study evaluated its acute and subchronic toxicity in\n                      <jats:italic>Wistar<\/jats:italic>\n                      rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Acute toxicity was assessed according to OECD Guideline 425 using a single oral dose of 5000\u2009mg\/kg. Subchronic toxicity was evaluated over 56\u2009days at doses of 150, 300 and 600\u2009mg\/kg\/day. Satellite groups (the control and the 600\u2009mg\/kg\/day group) were maintained for an additional 14\u2009days to observe the reversibility of any treatment\u2010related effects. Parameters studied included body\/organ weights, haematological, biochemical, lipid and histopathological profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No mortalities or signs of acute toxicity were observed during the 14\u2009days following extract administration. Subchronic administration did not affect survival or relative organ weights, although the 600\u2009mg\/kg dose induced minor structural alterations in affected organs. The extract significantly reduced body weight gain. At 150\u2009mg\/kg, the extract sex\u2010specifically improved lipid profiles by lowering triglycerides in males and increasing HDL cholesterol in females. Haematological assessment revealed a dose\u2010dependent increase in platelet counts in male rats at 600\u2009mg\/kg, which returned to baseline levels after the 14\u2010day recovery period. Elevated AST and ALT fully reversed in females post\u2010recovery; however, elevated ALT persisted at 600\u2009mg\/kg in males. Creatinine remained stable or decreased, and minor variations in urea concentrations in both sexes returned to baseline during recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>S. acuminatissimum<\/jats:italic>\n                      aqueous extract reduces body weight gain and improves lipid profiles at low\u2010to\u2010moderate doses (150\u2013300\u2009mg\/kg), providing its traditional use. However, the persistence of elevated ALT levels and focal leucocyte infiltration in males at 600\u2009mg\/kg indicates high\u2010dose hepatotoxicity, highlighting a narrow therapeutic window and the need for careful liver function monitoring during prolonged exposure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jt\/8985688","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:50:18Z","timestamp":1791287418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Acute and Subchronic Toxicity of\n                    <i>Stereospermum acuminatissimum<\/i>\n                    Stem Bark Aqueous Extract"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1677-8859","authenticated-orcid":false,"given":"Fabrice Mba","family":"Medou","sequence":"first","affiliation":[{"name":"Centre for Research on Health and Priority Pathologies Institute of Medical Research and Medicinal Plants Studies  Yaound\u00e9 Cameroon  impm-cameroun.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucienne Armelle","family":"Brooks","sequence":"additional","affiliation":[{"name":"Higher Teachers Training College University of Yaound\u00e9 I  Yaound\u00e9 Cameroon  uy1.uninet.cm"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1436-8178","authenticated-orcid":false,"given":"Nyemb","family":"Nyuna\u00ef","sequence":"additional","affiliation":[{"name":"Centre for Research on Health and Priority Pathologies Institute of Medical Research and Medicinal Plants Studies  Yaound\u00e9 Cameroon  impm-cameroun.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-2697","authenticated-orcid":false,"given":"Leonel Ntepe","family":"Mbah","sequence":"additional","affiliation":[{"name":"Centre for Research on Health and Priority Pathologies Institute of Medical Research and Medicinal Plants Studies  Yaound\u00e9 Cameroon  impm-cameroun.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-1848","authenticated-orcid":false,"given":"Esther Ngo Lemba","family":"Tom","sequence":"additional","affiliation":[{"name":"Higher Teachers Training College University of Yaound\u00e9 I  Yaound\u00e9 Cameroon  uy1.uninet.cm"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7647-4825","authenticated-orcid":false,"given":"Theodora Kowa","family":"Kopa","sequence":"additional","affiliation":[{"name":"The Centre for Research on Medicinal Plants and Traditional Medicine Institute of Medical Research and Medicinal Plants Studies  Yaound\u00e9 Cameroon  impm-cameroun.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-5197","authenticated-orcid":false,"given":"Rosette","family":"Megnekou","sequence":"additional","affiliation":[{"name":"Biotechnology Centre University of Yaound\u00e9 I  Yaound\u00e9 Cameroon  uy1.uninet.cm"},{"name":"Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon  uy1.uninet.cm"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2011.619182"},{"key":"e_1_2_11_2_2","article-title":"The Useful Plants of West Tropical Africa","author":"Burkill H. 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