{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:39:13Z","timestamp":1778945953824,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2083,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2083,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Metal-Based Drugs"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>Acyclic amine\u2010carboxyboranes were effective anti\u2010inflammatory agents in mice at 8 mg\/kg x 2.\nThese amine\u2010carboxyboranes were more effective than the standard indomethacin at 8 mg\/kg x\n2, pentoxifylline at 50 mg\/kg x 2, and phenylbutazone at 50 mg\/kg x 2. The heterocyclic amine\nderivatives as well as amine\u2010carbamoylboranes, carboalkoxyboranes, and cyanoboranes were\ngenerally less active. However, selected aminomethyl\u2010phosphonate\u2010N\u2010cyanoboranes\ndemonstrated greater than 60% reduction of induced inflammation. The boron compounds were\nalso active in the rat induced edema, chronic arthritis, and pleurisy screens, demonstrating\nactivity similar to the standard indomethacin. The compounds were effecive in reducing local\npain and decreased the tail flick reflex to pain. The derivatives which demonstrated good anti\u2010inflammatory\nactivity were effective inhibitors of hydrolytic lysosomal, and proteolytic enzyme\nactivities with IC<jats:sub>50<\/jats:sub>\n values equal to 10<jats:sup>-6<\/jats:sup>M\n in mouse macrophages, human leukocytes, and Be\nSal osteofibrolytic cells. In these same cell lines, the agents blocked prostaglandin\ncyclooxygenase activity with IC<jats:sub>50<\/jats:sub> values of 10<jats:sup>-6<\/jats:sup>M. In mouse macrophage and human\nleukocytes, 5\u2032 lipoxygenase activity was also inhibited by the boron derivatives with IC<jats:sub>50<\/jats:sub> values\nof 10<jats:sup>-6<\/jats:sup>M. These IC<jats:sub>50<\/jats:sub> values for inhibition of these enzyme activities are consistent with\npublished values of known anti\u2010inflammatory agents which target these enzymes.<\/jats:p>","DOI":"10.1155\/mbd.1995.1","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T12:33:53Z","timestamp":1173875633000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Anti\u2010Inflammatory Activityof Boron Derivatives in Rodents"],"prefix":"10.1155","volume":"2","author":[{"given":"Iris H.","family":"Hall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce S.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anup","family":"Sood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard F.","family":"Spielvogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen W.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,4,19]]},"container-title":["Metal-Based Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1995\/705129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MBD.1995.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T20:37:11Z","timestamp":1723149431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MBD.1995.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,19]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1155\/MBD.1995.1"],"URL":"https:\/\/doi.org\/10.1155\/mbd.1995.1","archive":["Portico"],"relation":{},"ISSN":["0793-0291","1687-5486"],"issn-type":[{"value":"0793-0291","type":"print"},{"value":"1687-5486","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4,19]]},"assertion":[{"value":"1994-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1994-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}