{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:02:17Z","timestamp":1723161737243},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Metal-Based Drugs"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>Clinical formulations of the antiarthritic drug aurothiomalate sometimes contain\nphenylmercury(ll) compounds as antimicrobial preservative agents and, in the presence of <jats:italic>para<\/jats:italic>\u2010chloromercuri\u2010benzoate, aurothiomalate is a potent inhibitor of collagenase. By <jats:sub>\u2009<\/jats:sub><jats:sup>1<\/jats:sup>H NMR\nspectroscopy, <jats:italic>para<\/jats:italic>\u2010hydroxymercuribenzoate and <jats:italic>para<\/jats:italic>\u2010hydroxymercuriphenylsulphonate were\nshown to react with aurothiomalate by complexing only with the terminal thiomalate of\naurothiomalate oligomers, thereby converting them to ring complexes. The reaction was also\ndetected by UV spectroscopy. The arylmercury complexes produced no change in the bulk of the\nthiomalate residues of aurothiomalate indicating considerable stability of the polymeric structure of\naurothiomalate in which each gold is bound to two thiolate residues. The potent inhibition of the\nmercurial induced collagenase activity may be due either to aurothiomalate or to a complex formed\nbetween the terminal thiomalate residues with the arylmercurial. The arylmercury complexes may be unsuitable as antimicrobials in solutions of aurothiomalate because of complexation with the\nterminal thiomalate residues.<\/jats:p>","DOI":"10.1155\/mbd.1996.269","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T12:33:53Z","timestamp":1173875633000},"page":"269-276","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reactions of the Antiarthritic Drug Aurothiomalate WithPhenylmercury(II) Compounds: NMR Studies"],"prefix":"10.1155","volume":"3","author":[{"given":"Garry G.","family":"Graham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diarmaid","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Sadler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,9,23]]},"container-title":["Metal-Based Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1996\/346524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MBD.1996.269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T20:25:19Z","timestamp":1723148719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MBD.1996.269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1155\/MBD.1996.269"],"URL":"https:\/\/doi.org\/10.1155\/mbd.1996.269","archive":["Portico"],"relation":{},"ISSN":["0793-0291","1687-5486"],"issn-type":[{"type":"print","value":"0793-0291"},{"type":"electronic","value":"1687-5486"}],"subject":[],"published":{"date-parts":[[1996,1]]},"assertion":[{"value":"1996-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}