{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:41:35Z","timestamp":1773002495191,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Metal-Based Drugs"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>The reactions of [2+3] cycloaddition of pyridylnitrile oxides to vinyl\u2010 and allylgermanes\nproceed regioselectively and afford 5\u2010Ge\u2010substituted isoxazolines\u20102. We have synthesized 9 new\npyridyl substituted 5\u2010Si(Ge)\u2010isoxazolines\u20102 and investigated their biological activity. The\nvasodilating, anticoagulant and cardioprotective activities of 5\u2010Si(Ge) substituted isoxazolines\u20102\nhave been studied in <jats:italic>vitro<\/jats:italic> and in <jats:italic>vivo<\/jats:italic>. Substitution of the silicon atom for the germanium one\nleads to the significant increase in vasodilating, antithrombotic and cardioprotective activity. The\ninsertion of the methylene group between Ge and the isoxazoline ring reduces the vasodilating\nactivity. The most active isoxazoline \u2010 3\u2010(5<jats:sub>\u2009<\/jats:sub><jats:sup>\u2035<\/jats:sup>\u2009\u2010triethylgermyl\u20103<jats:sub>\u2009<\/jats:sub><jats:sup>\u2035<\/jats:sup>\u2009\u2010isoxazolinyl)pyridine hydrochloride\nprotects the heart from rhythm disturbances and lethality during ischaemia\u2010reperfusion.<\/jats:p>","DOI":"10.1155\/mbd.1998.251","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T12:33:53Z","timestamp":1173875633000},"page":"251-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis, Vasodilating, Antithrombotic and Cardioprotective Activity of Pyridyl Substituted 5\u2010Silyl(Germyl)Isoxazolines\u20102"],"prefix":"10.1155","volume":"5","author":[{"given":"E.","family":"Lukevics","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Arsenyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Veveris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,7,14]]},"container-title":["Metal-Based Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1998\/463576.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MBD.1998.251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T15:01:28Z","timestamp":1723129288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MBD.1998.251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1155\/MBD.1998.251"],"URL":"https:\/\/doi.org\/10.1155\/mbd.1998.251","archive":["Portico"],"relation":{},"ISSN":["0793-0291","1687-5486"],"issn-type":[{"value":"0793-0291","type":"print"},{"value":"1687-5486","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]},"assertion":[{"value":"1998-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}