{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:13:25Z","timestamp":1770959605740,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Metal-Based Drugs"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>Metal complexes of a heterocyclic sulfonamides possessing very strong carbonic anhydrase (CA)\ninhibitory properties, i.e., 5\u2010(<jats:italic>p<\/jats:italic>\u2010fluorobenzenesulfonylamido)\u20101,3,4\u2010thiadiazole\u20102\u2010sulfonamide (p\u2010fluorobenzolamide)\nwere prepared. The new complexes contained metal ions such as Zn(II), Cu(II), Co(II), Ni(II),\nCd(II) and Mn(II). The new compounds were characterized by standard physico\u2010chemical procedures, and\nassayed as inhibitors of three CA isozymes, CA I, II and IV. Very good inhibition has been evidenced both\nfor the parent sulfonamides as well as for the prepared complexes, against all three investigated isozymes.\nSome of these new complexes as well as the parent sulfonamide, strongly lowered intraocular pressure (IOP)\nin normotensive rabbits when administered as a 2% solution into the eye.<\/jats:p>","DOI":"10.1155\/mbd.1999.67","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T12:33:53Z","timestamp":1173875633000},"page":"67-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Carbonic Anhydrase Inhibitors Part 72<sup>1<\/sup> Synthesis and AntiglaucomaProperties of Metal Complexes of <i>p<\/i>\u2010Fluorobenzolamide"],"prefix":"10.1155","volume":"6","author":[{"given":"Claudiu T.","family":"Supuran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Menabuoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Mincione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Briganti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Mincione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,2,4]]},"container-title":["Metal-Based Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1999\/696091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MBD.1999.67","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T20:41:14Z","timestamp":1723149674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MBD.1999.67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1155\/MBD.1999.67"],"URL":"https:\/\/doi.org\/10.1155\/mbd.1999.67","archive":["Portico"],"relation":{},"ISSN":["0793-0291","1687-5486"],"issn-type":[{"value":"0793-0291","type":"print"},{"value":"1687-5486","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]},"assertion":[{"value":"1999-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}