{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T16:10:05Z","timestamp":1723133405613},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Metal-Based Drugs"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>O\u2010Cholesteryl\u2010O\u2010phenyl\u2010N\u2010phenylphosphoramidate (<jats:bold>1<\/jats:bold>) and four organotin (lV) derivatives of\nthe ambidentate <jats:italic>O<\/jats:italic>\u2010cholesteryl\u2010<jats:italic>O<\/jats:italic> \u2010phenyl phosphorothioate ligand formulated as Me<jats:sub>3<\/jats:sub>\nSnOSPR\u2019R\u201d(<jats:bold>2<\/jats:bold>),\nPh<jats:sub>3<\/jats:sub>\nSnOSPR\u2019R\u201d(<jats:bold>3<\/jats:bold>), O\nSn(<jats:italic>n<\/jats:italic>\u2010Bu)OSPR\u2019R\u201d(<jats:bold>4<\/jats:bold>), S\nSn(<jats:italic>n<\/jats:italic>\u2010Bu)OSPR\u2019R\u201d(<jats:bold>5<\/jats:bold>), (R\u2019 = <jats:italic>O<\/jats:italic>\u2010phenyl;\nR\u201d= <jats:italic>O<\/jats:italic>\u2010cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel\ncarcinoma), OVCAR\u20105 (ovarium carcinoma) and SQC\u20101 UlSO (squamous cell cervix carcinoma)\ncell cultures. The results of the bioassay showed that these compounds possess potent antitumor\nactivities against the studied human carcinoma cell lines.<\/jats:p>","DOI":"10.1155\/mbd.2002.333","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T12:33:53Z","timestamp":1173875633000},"page":"333-335","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxic Activities of O\u2010Cholesteryl\u2010O\u2010Phenyl\u2010N\u2010Phenylphosphoramidate and ItsOrganometallic Tin(lV) Derivatives"],"prefix":"10.1155","volume":"8","author":[{"given":"Marcela","family":"L\u00f3pez-Cardoso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Garc\u00eda y","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymundo","family":"Cea-Olivares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda- Luisa","family":"Villareal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,8]]},"container-title":["Metal-Based Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2002\/560707.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MBD.2002.333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T15:12:00Z","timestamp":1723129920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MBD.2002.333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1155\/MBD.2002.333"],"URL":"https:\/\/doi.org\/10.1155\/mbd.2002.333","archive":["Portico"],"relation":{},"ISSN":["0793-0291","1687-5486"],"issn-type":[{"type":"print","value":"0793-0291"},{"type":"electronic","value":"1687-5486"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2002-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}