{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:03:12Z","timestamp":1791388992291,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012173","name":"China-Japan Friendship Hospital","doi-asserted-by":"publisher","award":["ZRJY2025-QMPY11"],"award-info":[{"award-number":["ZRJY2025-QMPY11"]}],"id":[{"id":"10.13039\/501100012173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gallstone disease is a condition affecting the digestive system, strongly linked to inflammation and lipid metabolism. Inflammatory markers derived from high\u2010density lipoprotein (HDL), incorporating both immune cells and HDL\u2010C, play a crucial role in assessing inflammatory responses. This study aims to explore the relationship between these HDL\u2010related inflammatory indices and gallstone disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study population was derived from the National Health and Nutrition Examination Survey (NHANES) 2017\u20132020 and 2021\u20132023 datasets. To assess the association between HDL\u2010related inflammatory indices and gallstone disease, weighted multivariable logistic regression and restricted cubic spline (RCS) analysis were utilized. Additionally, subgroup analysis was conducted to confirm the consistency of the results across different subpopulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 16,871 participants included in the study, 11.0% were diagnosed with gallstone disease. When compared to the lowest quartile, those in the highest quartile of lymphocyte\u2010to\u2010HDL cholesterol ratio (LHR), monocyte\u2010to\u2010HDL cholesterol ratio (MHR), neutrophil\u2010to\u2010HDL cholesterol ratio (NHR), and platelet\u2010to\u2010HDL cholesterol ratio (PHR) faced an elevated risk of gallstone disease by 58.6% (OR\u2009=\u20091.586, 95% CI: 1.143\u20132.2), 67.6% (OR\u2009=\u20091.676, 95% CI: 1.275\u20132.204), 68.7% (OR\u2009=\u20091.687, 95% CI: 1.244\u20132.287), and 42.7% (OR\u2009=\u20091.427, 95% CI: 1.101\u20131.849), respectively. The correlation between HDL\u2010related inflammatory indices and gallstone disease was more pronounced in females, individuals without diabetes or hypertension, nonsmokers, and those who consumed alcohol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This research identified a positive correlation between HDL\u2010related inflammatory indices and gallstone disease in a nationally representative sample. These indices can be derived from routine blood tests at no additional cost, making them practical and cost\u2010effective tools for early risk stratification and potential large\u2010scale screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/mi\/1925004","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:39:15Z","timestamp":1770266355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Link Between High\u2010Density Lipoprotein\u2010Related Inflammatory Indices and Gallstone Disease in U.S. 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