{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:55:32Z","timestamp":1784595332879,"version":"3.55.0"},"reference-count":96,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":174,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    The novel inflammatory biomarkers, including systemic immune\u2010inflammation index (SII), systemic inflammation response index (SIRI), and neutrophil\u2010to\u2010lymphocyte ratio (NLR), can contribute to predicting the future risk of various diseases. However, the impact of different physical activity (PA) domains on systemic inflammation remains unclear. The study aims to investigate the relationship between domain\u2010specific moderate\u2010to\u2010vigorous\u2010intensity PA (MVPA) and these inflammatory biomarkers among US adults.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Participants from the US National Health and Nutrition Examination Survey (NHANES) (2007\u20132018) were included in this study. The Global Physical Activity Questionnaire was used to assess self\u2010reported MVPA. MVPA was categorized into three domains, including occupation\u2010related MVPA (O\u2010MVPA), transportation\u2010related MVPA (T\u2010MVPA), and leisure\u2010time\u2010related MVPA (LT\u2010MVPA). SII, SIRI, and NLR were derived from the complete blood count results obtained at the NHANES Mobile Examination Centers (MEC). Weighted multivariable linear regression and propensity score matching (PSM) were used to examine the relationship between domain\u2010specific MVPA and inflammatory biomarkers. Additionally, stratified and mediation analyses were performed to assess potential effect modifications and mediators in this association.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The study included a total of 29,072 participants. Following PSM, weighted multivariable linear regression indicated a negative association between LT\u2010MVPA meeting PA guidelines (\u2009\u2265\u2009150\u2009min\/week) and circulating inflammatory biomarkers (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u221236, 95% confidence interval [CI]: \u221247 to \u221225,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.001 for SII;\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.09, 95% CI: \u22120.13 to \u22120.05,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.001 for SIRI;\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.08, 95% CI: \u22120.11 to \u22120.05,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.001 for NLR, respectively), adjusting for all potential covariates in model 2. Participants engaging in sufficient T\u2010MVPA (\u2265\u2009150\u2009min\/week) also exhibited lower SII and SIRI levels (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u221217, 95% CI: \u221232 to \u22122.4,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.023;\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.07, 95% CI: \u22120.11 to \u22120.03,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). Conversely, O\u2010MVPA showed no significant correlation with any inflammatory biomarkers (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &gt; 0.05). No significant effect modification was observed in the association between LT\u2010MVPA or T\u2010MVPA and inflammatory biomarkers (SII, SIRI, and NLR). Mediation analysis showed that body mass index (BMI) mediated the relationships between these inflammatory biomarkers and both LT\u2010MVPA and T\u2010MVPA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The impact of different PA domains on systemic inflammation varies significantly. Given the well\u2010established link between chronic inflammation and diseases such as cardiovascular disease (CVD), diabetes, and metabolic disorders, specific recommendations for PA categories should be provided, particularly targeting individuals with high systemic inflammatory responses.\n                  <\/jats:p>","DOI":"10.1155\/mi\/1989715","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T01:23:43Z","timestamp":1750814623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Domain\u2010Specific Physical Activity and Novel Inflammatory Biomarkers Among US Adults: Insights From NHANES 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