{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:27:21Z","timestamp":1790130441841,"version":"4.0.1"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,25]],"date-time":"2006-05-25T00:00:00Z","timestamp":1148515200000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministry of Education, University and Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>This study has  evaluated whether systemic changes of plasminogen\nactivator (t\u2010PA)  and plasminogen activator inhibitor\u20101 (PAI\u20101)\nparallel the adhesions development and whether they could be used\nas predictors of adhesion risk. This has been studied in an animal\nmodel of post\u2010surgical peritoneal adhesion by monitoring for 10\ndays the plasma and tissue levels of t\u2010PA and PAI\u20101. The results\nshowed that both tissular and plasmatic levels of t\u2010PA\nwere decreased in concomitance with the development of peritoneal\nadhesions. In contrast, PAI\u20101 was found increased into the tissue\nand into the plasma samples of the rats taken at 5 and 10 days\ntime points. Inflammatory mediators such as ICAM\u20101, VCAM\u20101, and\nIL\u20106 within the peritoneal lavage fluid also correlated with the\nadhesion formation process. In conclusion, post\u2010surgical\nperitoneal adhesions provide alterations of local inflammatory\ncomponents and local and systemic fibrinolytic components,\npossibly with PAI\u20101 quenching t\u2010PA. This may have potential for\nthe identification of high\u2010risk patients.<\/jats:p>","DOI":"10.1155\/mi\/2006\/13901","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T10:09:20Z","timestamp":1150711760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Plasma Levels of t\u2010PA and PAI\u20101 Correlate With the Formation of Experimental Post\u2010Surgical Peritoneal Adhesions"],"prefix":"10.1155","volume":"2006","author":[{"given":"Clara Di","family":"Filippo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Falsetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"De Pascale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Tufariello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"De Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"D\u2032Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cennamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,25]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80196-6"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)60563-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107688908200909"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(90)90037-2"},{"key":"e_1_2_1_5_2","first-page":"172","article-title":"Inhibition of postsurgical adhesions in a standardized rabbit model: intraperitoneal treatment with tissue plasminogen activator","volume":"36","author":"Orita H","year":"1991","journal-title":"International Journal of Fertility"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00859.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.1.69"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.556"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2006\/013901.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MI\/2006\/13901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T16:32:46Z","timestamp":1717691566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MI\/2006\/13901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/MI\/2006\/13901"],"URL":"https:\/\/doi.org\/10.1155\/mi\/2006\/13901","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"013901"}}