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Serum IL\u201010 concentrations were increased in patients with\nactive UC but not in those with active CD  when compared with normal control subjects.  A time course study\nshowed that in patients with UC and CD, serum concentrations of IL\u20106 and C\u2010reactive protein\nincreased during the acute phase and returned to normal as patients go into remission. Notably,\nserum IL\u201010 concentrations increased during the phase of disease resolution and declined\nthereafter regardless of the treatment modality. Gel filtration analysis indicated that IL\u201010\ncirculated predominantly as a dimer. In conclusion, this study shows that serum IL\u201010 is\nincreased during disease recovery in patients with inflammatory bowel disease, and may be a\nhelpful marker in monitoring disease status.<\/jats:p>","DOI":"10.1155\/mi\/2006\/26875","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T19:58:50Z","timestamp":1163620730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Interleukin\u201010 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase"],"prefix":"10.1155","volume":"2006","author":[{"given":"Keiichi","family":"Mitsuyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Tomiyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Takaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Kuwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehiko","family":"Kitazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Sata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,11]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"191","volume-title":"Inflammatory Bowel Disease","author":"Podolsky D K","year":"2000"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-3477-0_7"},{"key":"e_1_2_1_3_2","first-page":"78","volume-title":"Inflammatory Bowel Disease: From Bench to Bedside","author":"Shanahan","year":"1994"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-199907000-00003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109263251306"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91182-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.6.2081"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90153-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.147.11.3815"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50091-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-065X.1992.tb01409.x","article-title":"Bacterial toxin-induced cytokine production studied at the single-cell level","author":"Andersson","year":"1992","journal-title":"Immunological Reviews"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80068-P"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90692-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4947.1041"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00365521.1984.12199901","article-title":"The OMGE multinational inflammatory bowel disease survey 1976\u20131982. 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