{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:08:51Z","timestamp":1791148131408,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T00:00:00Z","timestamp":1140480000000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Recently, it has been reported that TLR2 on macrophages plays a unique\nrole in the inflammatory response and host defense to infection\nwith Borrelia burgdorferi (Bb) which is an etiologic agent of\nLyme disease. Experimental studies show that PMNs also play an\nessential role in infection control by Bb. However,\nthere is no available data about TLR2 expression on PMN in the\ncourse of Lyme disease. In the present study, TLR2 expression and\nproduction of IL\u20101<jats:italic>\u03b2<\/jats:italic> and IL\u20106 as well as their natural\nregulators (sIL\u20101RII, IL\u20101Ra and sIL\u20106R<jats:italic>\u03b1<\/jats:italic>, sgp130, resp) by\nPMN of peripheral blood in patients with Lyme disease were\nexamined. For the purpose of comparison, the same activity of\nautologous peripheral blood mononuclear cells (PBMCs) was estimated. An\neffect of rhIL\u201015 on TLR2 and cytokine secretion was also studied.\nIncreased TLR2 expression in unstimulated neutrophils suggests an\nimportant role of these cells in mechanism recognition of B\nburgdorferi in patients with Lyme disease. The relationship\nbetween IL\u20101<jats:italic>\u03b2<\/jats:italic> and IL\u20106 as well as their regulators by\nunstimulated PMN and PBMC, observed in the present study, may lead\nto enhanced IL\u20106\u2010 and to inhibition of IL\u20101<jats:italic>\u03b2<\/jats:italic>\u2010mediated\nreactions in this patient group. Changes in the TLR2 expression\nafter rhIL\u201015 stimulation appear to have a favorable effect on\nmechanism recognition of Bb. The relations between IL\u20106\nand its regulators (sIL\u20106R<jats:italic>\u03b1<\/jats:italic> and sgp130) as well as between\nIL\u20101<jats:italic>\u03b2<\/jats:italic> and its regulators (IL\u20101Ra and sIL\u20101RII) after rhIL\u201015\nstimulation may lead to enhanced IL\u20101<jats:italic>\u03b2<\/jats:italic>\u2010 and IL\u20106\u2010mediated\ninflammatory reactions in the course of Lyme disease.<\/jats:p>","DOI":"10.1155\/mi\/2006\/32071","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T12:45:21Z","timestamp":1144241121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["TLR2 Expression in Relation to IL\u20106 and IL\u20101<i>\u03b2<\/i> and theirNatural Regulators Production by PMN and PBMC in Patients withLyme Disease"],"prefix":"10.1155","volume":"2006","author":[{"given":"Ewa","family":"Jablonska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Marcinczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,21]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031237"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1630"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01615-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.10.5268"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.69.3.474"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094351"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1078"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.987"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.47.33419"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/339341"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80066-2"},{"key":"e_1_2_1_12_2","first-page":"249","article-title":"Effect 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