{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:14:52Z","timestamp":1780550092028,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T00:00:00Z","timestamp":1142812800000},"content-version":"vor","delay-in-days":78,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Beh\u00e7et\u2032s disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. <jats:italic>MEFV<\/jats:italic> gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of\ndeath\u2010domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. This study was designed to determine if mutations in pyrin domain of MEFV gene are involved in BD. <jats:italic>Methods<\/jats:italic>. We analyzed the pyrin domain of MEFV gene in 54 Turkish patients with BD by PCR\u2010analysis and direct sequencing. <jats:italic>Results<\/jats:italic>. Neither deletion or insertion mutations nor point mutations in pyrin domain were found in any patient. <jats:italic>Conclusion<\/jats:italic>. Although pyrin gene mutations have been reported in patients with BD, pyrin domain is not mutated. However, alterations in other regions of MEFV gene and interaction\nbetween pyrin domains are needed to be further investigated.<\/jats:p>","DOI":"10.1155\/mi\/2006\/41783","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T12:45:21Z","timestamp":1144241121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Beh\u00e7et\u2032s Disease"],"prefix":"10.1155","volume":"2006","author":[{"given":"Ahmet","family":"Dursun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Gul","family":"Durakbasi-Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Gul","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerrin G\u00fclin","family":"Gulbahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recep","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cengiz","family":"Yakicier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"e_1_2_1_2_2","first-page":"S6","article-title":"Beh\u00e7et\u2032s disease: an update on the pathogenesis","volume":"19","author":"Gul A","year":"2001","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-2333-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80539-5"},{"key":"e_1_2_1_5_2","first-page":"S35","article-title":"MEFV mutations are increased in Beh\u00e7et\u2032s disease (BD) and are associated with vascular \n                   involvement","volume":"21","author":"Atagunduz P","year":"2003","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740510017931"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-25"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.10.3223"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.3.851"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1101-241"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400774"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197505000-00001"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.5.299"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.9.1027"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050361"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01905-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.07.007"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80134-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00056-2"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00309-7"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00056-X"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.8.961"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2135380100"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104730200"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00384-4"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104901009"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/bj20030304","article-title":"The PAAD\/PYRIN-only protein POP1\/ASC2 is a modulator of ASC-mediated \n                   nuclear-factor-? 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