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STZ\u2010hyperglycemic rats had impaired\nlevels of the enzyme HO\u20101 within the ciliary bodies if\ncompared with the nondiabetic rats. STZ\u2010hyperglycemic rats also\npredisposed the eye to produce high levels of both the cytokines\nIL\u20101<jats:italic>\u03b2<\/jats:italic>\n and CXCL8. Subsequent EIU further and significantly\n(<jats:italic>P<\/jats:italic> &lt; .01)\n increased the cytokines production, an effect partly\nprevented by hemin treatment. Most importantly, hemin, an inducer\nof heme oxygenase expression and activity, recovered the huge\nnumber of infiltrated polymorphonuclear leukocytes PMN within the\nciliary bodies associated with STZ\u2010hyperglycemic state and EIU\ndamage. Impairment of the stress\u2010sensitive enzyme HO\u20101 in\nSTZ\u2010hyperglycemic rats increases and prolongs the inflammatory\nresponse to EIU.<\/jats:p>","DOI":"10.1155\/mi\/2006\/60285","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T14:09:20Z","timestamp":1150726160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hyperglycemia in Streptozotocin\u2010Induced DiabetesLeads to Persistent Inflammation and Tissue Damage FollowingUveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase\u20101"],"prefix":"10.1155","volume":"2006","author":[{"given":"Settimio","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"D\u2032Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Capuano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Petronella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Di Filippo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,17]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.3.290"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2003.08.014"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.279.6.L1029"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00535.2001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2.454"},{"key":"e_1_2_1_6_2","first-page":"1107","article-title":"Interleukin-1a, interleukin-1\u00df, and tumor necrosis factor gene expression in endotoxin-induced uveitis","volume":"35","author":"Yoshida M","year":"1994","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3973"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.3.2004202"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(85)90029-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22711.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.00932.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.3.778"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.3.803"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1076"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00231.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.8.663"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)00854-7"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/15353702-0322805-15"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00644.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(96)05948-5"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.5.705"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2006\/060285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MI\/2006\/60285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T20:31:13Z","timestamp":1717705873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MI\/2006\/60285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/MI\/2006\/60285"],"URL":"https:\/\/doi.org\/10.1155\/mi\/2006\/60285","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"060285"}}