{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:19:11Z","timestamp":1753888751594,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T00:00:00Z","timestamp":1159920000000},"content-version":"vor","delay-in-days":276,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministero Italiano Universit\u00e0 e Ricerca"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. HLA genes play a role in the predisposition of several diseases. The aim was to\nanalyze the prevalence of HLA class I phenotypes and HLA\u2010DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). <jats:italic>Methods<\/jats:italic>. 69 patients with AICU, and 200 healthy subjects. <jats:italic>Results<\/jats:italic>. Subjects with HLA\u2010B44 and HLA\u2010Cw5 antigens were more\nrepresented in patients with AICU than in control group. Subjects with HLA\u2010A11, HLA\u2010B13, HLACw4,\nand HLA\u2010Cw7 antigen were more represented in control group than in patients with AICU.\nMultiple logistic regression demonstrated an association of HLA\u2010Cw4 and HLA\u2010Cw7 with a lower\nrisk of AICU, whereas carriers of HLA\u2010B44 phenotype had a higher risk of AICU. No differences\nwere found between patients and controls as regards to HLA\u2010DRB1* genotype. <jats:italic>Conclusions<\/jats:italic>. We\nobserved an association between some HLA class\u2010I antigens and AICU. To the best of our\nknowledge this is the first description of such association.<\/jats:p>","DOI":"10.1155\/mi\/2006\/62489","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:58:50Z","timestamp":1163638730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and\/or NSAIDs Hypersensitivity"],"prefix":"10.1155","volume":"2006","author":[{"given":"Maria Luisa","family":"Pacor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Di 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