{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:01:55Z","timestamp":1765609315352,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T00:00:00Z","timestamp":1141257600000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:italic>Introduction.<\/jats:italic> Family member with IBD is the greatest risk factor for developing the disease. The hematological profileof first\u2010degree relatives (FDRs) of Crohn\u2032s disease (CD) patients was studied in order to identify healthy FDRs at risk to develop disease. <jats:italic>Materials and methods.<\/jats:italic> Thirty CD\npatients, 90 FDRs, and 28 non\u2010related individuals (controls) were enrolled. Hematological profile and C\u2010reactive protein were determined. <jats:italic>Results.<\/jats:italic> All hematological parameters were significantly different in CD patients compared to controls, with significantly higher levels of CRP, WBC, PMN, MONO, and PLT and\nlower Hb and lymphocyte count. The hematological profile of FDRs showed values between the controls and CD patients with ten FDRs that their parameters matched those of CD patients and significantly different from other FDRs. This group was defined as high\u2010risk relatives (HRRs). <jats:italic>Conclusions.<\/jats:italic> Analysis of the hematological profile and CRP level might be proven as a fast,\nreliable, and less money\u2010consuming tool to identify FDRs with a probable increased risk to develop the disease.<\/jats:p>","DOI":"10.1155\/mi\/2006\/74785","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T12:45:21Z","timestamp":1144241121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Subgroup of First\u2010Degree Relatives of Crohn\u2032s Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn\u2032s Disease Patients Than of Normal Individuals"],"prefix":"10.1155","volume":"2006","author":[{"given":"Broide","family":"Efrat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goren","family":"Iris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scapa","family":"Eitan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisari","family":"Yona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,2]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-59-2-133"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529109025046"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(84)80014-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/00855920310002717","article-title":"IBD and genetics: new developments","author":"Oostenbrug L E","year":"2003","journal-title":"Scandinavian Journal of Gastroenterology. 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