{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:54:51Z","timestamp":1780545291860,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460272"],"award-info":[{"award-number":["82460272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["[2021] 5612"],"award-info":[{"award-number":["[2021] 5612"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["gyfyxkyc-2023\u201305"],"award-info":[{"award-number":["gyfyxkyc-2023\u201305"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["gyfynsfc-2021-08"],"award-info":[{"award-number":["gyfynsfc-2021-08"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["YJ22020"],"award-info":[{"award-number":["YJ22020"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"publisher","award":["gzwkj2022-489"],"award-info":[{"award-number":["gzwkj2022-489"]}],"id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    The neutrophil\u2010to\u2010lymphocyte ratio (NLR) is an important marker of inflammation. An increased NLR has been detected in the blood of patients with epilepsy. However, the correlation between varying NLRs and epileptic seizures (ESs) is still unclear.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A retrospective analysis was conducted, and patients were divided into two groups based on whether they had ES upon admission. Comprehensive data were collected, including routine blood tests, demographic information, and medical histories. The NLR was calculated by dividing the percentage of neutrophils by the percentage of lymphocytes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In total, 414 patients were included (284 males, 151 females; aged 18\u201390 years), with 271 in the experimental group and 143 in the control group. No significant differences in the NLR were found between the groups (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.164). Nonetheless, when NLRs were categorized, a \u201cV\u201d\u2010shaped link with ES was observed. An NLR of 2\u20133 correlated with the lowest seizure incidence. Higher NLRs were associated with increased neutrophil and decreased lymphocyte counts. Patients with an NLR\u2009&lt;\u20092 had the lowest infection rates and the highest cerebrovascular disease exposure, whereas those with an NLR\u2009&gt;\u20093 had the highest infection rates and were the oldest.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    NLR modifications can serve as potential predictive markers for ES. However, the relationship between the NLR and ES is not linear. The factors contributing to these variations are multiple and complex. An NLR of 2\u20133 may represent an equilibrium point. An elevated NLR indicates pronounced inflammatory responses, while a low NLR can have more complex causes.\n                  <\/jats:p>","DOI":"10.1155\/mi\/2247724","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:19:16Z","timestamp":1742368756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neutrophil\u2010to\u2010Lymphocyte Ratio as a Potential Predictive Marker for Epileptic Seizures: Unveiling the \u201cV\u201d\u2010Shaped Link"],"prefix":"10.1155","volume":"2025","author":[{"given":"Xianmei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0517-4723","authenticated-orcid":false,"given":"Likun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-7794","authenticated-orcid":false,"given":"Guofeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60456-6"},{"key":"e_1_2_14_2_2","unstructured":"WHO Epilepsy 2024 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/epilepsy#:~:text=Rates%20of%20disease&text=Globally%2C%20an%20estimated%205%20million as%20139%20per%20100%20000."},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003509"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11860-6"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.11.022"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2024.109907"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16895"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.3880"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2021.106770"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109372"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02840-8"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02482-2"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105823"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2019.577142"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00974"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577343"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9100683"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2020.1155"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12684"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20197374"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16512"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814378"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01817-1"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0095-2022"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-006462"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109177"},{"key":"e_1_2_14_27_2","doi-asserted-by":"crossref","unstructured":"KuangZ. 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