{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:45:42Z","timestamp":1777866342811,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":119,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2410200"],"award-info":[{"award-number":["2023YFC2410200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to examine the associations between body mass index (BMI) and hearing loss (HL), and to explore the mediating role of inflammation using data from the National Health and Nutrition Examination Survey (NHANES).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of 5489 participants aged \u226520 years from six NHANES cycles (2005\u20132012 and 2015\u20132018) was evaluated. Linear regression analysis was used to assess the relationships between BMI and HL. Three models were developed: (1) the association between BMI and low\u2010frequency (LF) HL and speech\u2010frequency (SF) HL; (2) the association between BMI and inflammatory markers (systemic immune\u2010inflammatory index [SII] and systemic inflammatory response index [SIRI]); and (3) the association between SII\/SIRI and LFHL\/SFHL. Mediation analyses were conducted to evaluate the role of SII and SIRI in the relationship between BMI and HL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the three groups, participants with higher BMIs exhibited higher values for SII, SIRI, LFHL, and SFHL. Positive correlations were observed between BMI and inflammation, inflammation and HL, and BMI and HL in all models. Mediation analysis revealed that SII mediated 9.87% of the effect of BMI on LFHL and 8.25% on SFHL, while SIRI mediated 17.47% and 16.59% of these effects, respectively. Although modest, these consistent mediating effects suggest inflammation contributes to, but does not wholly account for, the obesity\u2013hearing relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicates that systemic inflammatory markers (SII and SIRI) partially mediate the association between BMI and HL. These findings suggest that inflammation represents a potential mechanistic link in obesity\u2010related auditory dysfunction. Future longitudinal studies are needed to validate these pathways and inform targeted prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/mi\/2294661","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:30:14Z","timestamp":1777537814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Systemic Inflammatory Indices (SII and SIRI) as Mediators Between BMI and Hearing Loss"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4375-995X","authenticated-orcid":false,"given":"Hesen","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-7241","authenticated-orcid":false,"given":"Wenkao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-8903","authenticated-orcid":false,"given":"Yu","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-7221","authenticated-orcid":false,"given":"Yunfei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5989-4266","authenticated-orcid":false,"given":"Yunping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-020-00862-9"},{"key":"e_1_2_13_2_2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0140-6736(21)00516-X","article-title":"Hearing Loss Prevalence and Years Lived With Disability, 1990\u20132019: Findings From the Global Burden of Disease Study 2019","volume":"397","year":"2021","journal-title":"The Lancet"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.18332\/tid\/208812"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.2876"},{"key":"e_1_2_13_5_2","volume-title":"Biomarkers of Systemic Inflammation and Risk of Incident Hearing Loss","author":"Gupta S.","year":"2018"},{"key":"e_1_2_13_6_2","first-page":"4452","article-title":"High Risk of Sensorineural Hearing Loss in Men Born Small for Gestational Age With and Without Obesity or Height Catch-up Growth: A Prospective Longitudinal Register Study on Birth Size in 245,000 Swedish Conscripts","volume":"8","author":"Marie-Louise B.","year":"2005","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.04.026"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13401"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.03.020"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21039"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2015.00955"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986710792927895"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt075"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2014.891057"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz023"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1369492"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115863"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-021-00752-6"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S283835"},{"key":"e_1_2_13_20_2","first-page":"1","article-title":"National Health and Nutrition Examination Survey: Sample Design, 2011\u20132014. 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