{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:51:26Z","timestamp":1772992286405,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ60296"],"award-info":[{"award-number":["2023JJ60296"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long noncoding RNAs (lncRNAs) are involved in regulating inflammatory responses in sepsis. This study aimed to investigate the potential roles of lncRNA SNHG5 in the pathogenesis of sepsis\u2010induced coronary artery injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cecal ligation and puncture were used to establish a sepsis mouse model. Serum and coronary artery tissues were collected to assess inflammatory markers and lncRNA expression using enzyme\u2010linked immunosorbent assay (ELISA) and real\u2010time quantitative polymerase chain reaction (qPCR). In vitro, mouse aortic endothelial cells were exposed to septic serum. The SNHG5\/miR\u2010377\u20103p\/methionyl aminopeptidase 2 (METAP2) axis was investigated using dual\u2010luciferase reporter gene experiments. Loss\u2010of\u2010function, gain\u2010of\u2010function, and rescue assays were performed to elucidate the functions of these genes in sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Septic mice exhibited elevated systemic tumor necrosis factor alpha and interleukin (IL)\u20106 levels, as well as dysregulated endothelial markers (eNOS downregulation and ET\u20101 upregulation). Among the inflammation\u2010related lncRNAs, SNHG5 was the most significantly upregulated in septic coronary arteries and serum. Bioinformatic and experimental analyses revealed that SNHG5 acts as a competitive endogenous RNA (ceRNA) for miR\u2010377\u20103p, thereby upregulating (METAP2). Silencing SNHG5 or METAP2 reduced IL\u20108 secretion and endothelial apoptosis; these effects were reversed by miR\u2010377\u20103p inhibition. Conversely, METAP2 overexpression increased IL\u20108 secretion and apoptosis, which were attenuated by miR\u2010377\u20103p mimics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified the SNHG5\/miR\u2010377\u20103p\/METAP2 axis as a novel regulatory pathway in sepsis\u2010induced endothelial inflammation and apoptosis. SNHG5 promotes METAP2 expression by sponging miR\u2010377\u20103p, leading to increased IL\u20108 secretion and endothelial dysfunction. These findings provide new insights into lncRNA\u2010mediated mechanisms in sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/mi\/2519086","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:49:21Z","timestamp":1772977761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SNHG5 Exacerbates Sepsis\u2010Induced Inflammatory Injury in Coronary Artery Endothelial Cells by Regulating METAP2\u2010Mediated IL\u20108 Secretion"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-3630","authenticated-orcid":false,"given":"Tingzhi","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4460-7457","authenticated-orcid":false,"given":"Ding","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-8083","authenticated-orcid":false,"given":"Lihui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0379-9166","authenticated-orcid":false,"given":"Yan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5491"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.962470"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2017.08.003"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02926-2"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.08.066"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5173-1"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa070"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-021-09901-4"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112756"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.563126"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-020-00228-5"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-507"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvab008"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110016"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1248"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(20000601)77:3<465::AID-JCB11>3.0.CO;2-M"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201910-1911TR"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.2741\/3835"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05932-8"},{"key":"e_1_2_12_20_2","article-title":"Biomarkers of Endothelial Activation\/Dysfunction Distinguish Sub-Groups of Ugandan Patients With Sepsis and Differing Mortality Risks","volume":"5","author":"Clark D. 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