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ATOJIN is a natural product composed of\n                    <jats:italic>Phellodendron amurense Ruprecht<\/jats:italic>\n                    (PAR),\n                    <jats:italic>Schizonepeta tenuifolia<\/jats:italic>\n                    (ST),\n                    <jats:italic>Sophora flavescens<\/jats:italic>\n                    (SF),\n                    <jats:italic>Glycyrrhiza uralensis<\/jats:italic>\n                    (GU), and\n                    <jats:italic>Liriope platyphylla<\/jats:italic>\n                    (LP), all known for their anti\u2010inflammatory properties. This study aims to evaluate the therapeutic potential of ATOJIN in a 2,4\u2010dinitrochlorobenzene (DNCB)\u2010induced AD mouse model by assessing its effects on inflammation and immune regulation. The therapeutic efficacy of ATOJIN was evaluated through the analysis of white blood cell subtypes, serum immunoglobulin E (IgE) levels, pro\u2010inflammatory cytokines, and histological assessments of inflammatory and mast cell infiltration, focusing on systemic immune modulation. ATOJIN effectively alleviated AD lesions and symptoms in DNCB\u2010induced mice, demonstrating significant improvements in dermatitis scores, ear thickness, and spleen weight. It also reduced epidermal thickness and the infiltration of inflammatory and mast cells. Furthermore, ATOJIN modulated serum levels of IgE and pro\u2010inflammatory cytokines, including interleukin (IL)\u22122, IL\u20104, IL\u20106, and tumor necrosis factor (TNF)\u2010\u03b1, indicating systemic anti\u2010inflammatory effects. These results suggest that ATOJIN mitigates AD symptoms by modulating inflammatory responses, and its efficacy, comparable to or even superior to that of the topical standard\u2010of\u2010care tacrolimus, highlights its potential as a promising standalone oral therapeutic agent for the systemic management of AD.\n                  <\/jats:p>","DOI":"10.1155\/mi\/3444278","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:18:06Z","timestamp":1773479886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ATOJIN: A Natural Products Mixture, Alleviates Atopic Dermatitis in DNCB\u2010Induced NC\/Nga Mice"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-4150","authenticated-orcid":false,"given":"Sang-Eun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Jin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Sun","family":"Yim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-430X","authenticated-orcid":false,"given":"Seong-Gyu","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17544"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S467327"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.10.023"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.04.004"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.062"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00829-4"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.01.010"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0209-1"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8020027"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.20344\/amp.11963"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.11.042"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.01.020"},{"key":"e_1_2_12_14_2","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/821967","article-title":"Topical Application of Chrysanthemum indicum L. 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