{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:51:02Z","timestamp":1784119862117,"version":"3.55.0"},"reference-count":74,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Severe acute pancreatitis (SAP) is associated with high morbidity and mortality. Microcirculatory dysfunction is a critical pathological event in this process and a primary contributor to organ failure (OF). Despite the pivotal role of P\u2010selectin in mediating the adhesion of activated platelets and leukocytes to the vascular endothelium, a process central to microcirculatory dysfunction, effective therapeutic interventions for SAP remain limited.\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    , a traditional Chinese medicinal (TCM) herb, possesses well\u2010documented pharmacological properties, including anti\u2010inflammatory, anticoagulant, and microcirculation\u2010improving effects. This review synthesizes recent advances in understanding the bioactive components of\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    , which ameliorate microcirculation by modulating P\u2010selectin expression and activity through mechanisms targeting its transcription, translation, or post\u2010translational activation. Given the current lack of direct evidence in the context of SAP, we synthesized extensive findings from studies on cardiovascular, gastrointestinal, and inflammatory diseases, as well as from relevant acute pancreatitis (AP)\/SAP models. These collective data demonstrate that\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    effectively inhibits platelet aggregation, attenuates leukocyte adhesion, mitigates endothelial injury, and improves perfusion. Substantial evidence suggests that the bioactive compounds derived from\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    function as effective agents against microcirculatory dysfunction by targeting P\u2010selectin. Leveraging this well\u2010defined mechanistic pathway and the promising therapeutic efficacy observed in AP\/SAP models, targeting P\u2010selectin with\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    \u2019s bioactive compounds emerges as a compelling novel strategy for SAP\u2010associated microcirculatory dysfunction, laying a groundwork for subsequent validation studies.\n                  <\/jats:p>","DOI":"10.1155\/mi\/4925035","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:47:42Z","timestamp":1769150862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Progress on\n                    <i>Salvia miltiorrhiza<\/i>\n                    Bioactive Components Regulating P\u2010Selectin for Microcirculatory Improvement: Potential Implications in Acute Pancreatitis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9685-8299","authenticated-orcid":false,"given":"Yali","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weian","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-176X","authenticated-orcid":false,"given":"Honglian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6756-8109","authenticated-orcid":false,"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-5541","authenticated-orcid":false,"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7338-6563","authenticated-orcid":false,"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002645"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.06.004"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.011"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.06.005"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30004-8"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.010"},{"key":"e_1_2_12_8_2","first-page":"165","article-title":"Progress in Research on Etiology and Pathogenesis of Severe Acute Pancreatitis","volume":"7","author":"Wei R.-S.","year":"2023","journal-title":"China Science and Technology Journal Database"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.039"},{"key":"e_1_2_12_10_2","first-page":"502","article-title":"The Relationship of Coagulation Factors to Clinical Complications of Acute Pancreatitis","volume":"81","author":"Ranson J. H.","year":"1977","journal-title":"Surgery"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1981.42.05.805"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000186248.89081.44"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2014.07.015"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000240617.66215.d2"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000739"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2008.11.008"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1074-5"},{"key":"e_1_2_12_18_2","first-page":"103","article-title":"Protective and Therapeutic Effect of Heparin in Acute Pancreatitis","volume":"59","author":"Ceranowicz P.","year":"2008","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106621"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101709"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040882"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112493"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2020.3.13"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S388216"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181706d67"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2015.1051659"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750022959"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000171465"},{"key":"e_1_2_12_29_2","first-page":"609","article-title":"Therapeutic Effect of Exogenous Ghrelin in the Healing of Gingival Ulcers is Mediated by the Release of Endogenous Growth Hormone and Insulin-Like Growth Factor-1","volume":"68","author":"Cieszkowski J.","year":"2017","journal-title":"Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society"},{"key":"e_1_2_12_30_2","first-page":"87","article-title":"Treatment With Ghrelin Accelerates the Healing of Acetic Acid-Induced Gastric and Duodenal Ulcers in Rats","volume":"60","author":"Ceranowicz P.","year":"2009","journal-title":"Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061643"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000517"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31310-6"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12743"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000212098"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.04.018"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7775"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116697"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1100351"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.09.008"},{"key":"e_1_2_12_41_2","first-page":"101","article-title":"The Effect of Labiatae on Acute Necrotizing Pancreatitis in Rats With Lung Injury","volume":"11","author":"Zhang J.","year":"2002","journal-title":"Chinese Journal of Emergency Medicine"},{"key":"e_1_2_12_42_2","first-page":"496","article-title":"The Effect of Labiatae on Changes of Gastric Mucosal Microcirculation in Rats With Acute Necrotizing Pancreatitis","volume":"28","author":"Zhang J.","year":"2002","journal-title":"Journal of Jiangsu Medical College"},{"key":"e_1_2_12_43_2","first-page":"97","article-title":"The Effect of Labiatae on Renal Injury in Rats With Acute Necrotizing Pancreatitis","volume":"12","author":"Zhang J.","year":"2003","journal-title":"Zhejiang Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5390482"},{"key":"e_1_2_12_45_2","first-page":"1","article-title":"Effect of Salvia Miltiorrhiza on Lipid Peroxidation of Multiple Organs in Rats With Early Stage Severe Acute Pancreatitis","volume":"13","author":"Li L.","year":"2005","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine in Digestive Diseases"},{"key":"e_1_2_12_46_2","first-page":"576","article-title":"Effect of Danshen Injection on Soluble Adhesion Molecules in Acute Edematous Pancreatitis","volume":"24","author":"Zhang M.","year":"2006","journal-title":"Journal of Guangdong Medical University"},{"key":"e_1_2_12_47_2","first-page":"69","article-title":"Study on the Preventive Effects of Compound Danshen Injection on Acute Pancreatitis in Rats","volume":"13","author":"Shi J.","year":"1992","journal-title":"Journal of Xi\u2019an Jiaotong University (Medical Sciences)"},{"key":"e_1_2_12_48_2","first-page":"20","article-title":"Influence of Danshen and Glucocorticoid on Inositol Triphosphate and Calcium Metabolism in Rats With Severe Acute Pancreatitis","volume":"5","author":"Wang H.","year":"2014","journal-title":"Pharmacy and Clinics of Chinese Materia Medica"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2809"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-009-9114-6"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005282630"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.116871"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6652"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03859.x"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.07.019"},{"key":"e_1_2_12_56_2","first-page":"738","article-title":"Effect of Danshen Injection on Expression of Platelet Membrane Glycoproteins in Patients With Type II Diabetes Mellitus","volume":"10","author":"Zhang M.","year":"2003","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"e_1_2_12_57_2","first-page":"415","article-title":"Effect of Composite Salviae Dropping Pill on Function of Platelet Activation in Patients With Unstable Angina Pectori","volume":"6","author":"Jin L.","year":"2000","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_12_58_2","first-page":"882","article-title":"Effect of Compound Salvia Injection on Blood Coagulation in Patients With Traumatic Cerebral Infarction","volume":"10","author":"Zhang R.","year":"2004","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13879"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.11.4183.4183"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.3.550.550"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90292-4"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.3.876"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.5.1381"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8891544"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13139-X"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305378"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115197"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.08.145"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.59.7.0016"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500729"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2006.10.011"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-18-30"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02844.x"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/mi\/4925035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/mi\/4925035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/mi\/4925035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:47:45Z","timestamp":1769150865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/mi\/4925035"}},"subtitle":[],"editor":[{"suffix":"Jr.","given":"Zoltan","family":"Rakonczay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/mi\/4925035"],"URL":"https:\/\/doi.org\/10.1155\/mi\/4925035","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4925035"}}