{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:35:37Z","timestamp":1773012937327,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":303,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Inflammatory bowel disease (IBD), including ulcerative colitis (UC), involves chronic gastrointestinal inflammation, with tumor necrosis factor alpha (TNF\u2010\u03b1) playing a key role. Anti\u2010TNF therapy is widely used, but not all UC patients respond, suggesting additional contributing factors. Gut microbiota alterations, particularly dysbiosis, may influence treatment outcomes. This study examines the relationship between\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    (\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    ) density and TNF\u2010\u03b1 expression in UC patients receiving anti\u2010TNF therapy. Biopsy samples from responders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), nonresponders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) were analyzed using real\u2010time PCR.\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    density was significantly higher in nonresponders than in responders (3.2\u2010fold,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.05) and controls (fivefold,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.05). TNF\u2010\u03b1 expression was elevated in both UC groups. These findings suggest\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    may contribute to anti\u2010TNF therapy resistance by modulating intestinal inflammation, highlighting its potential as a biomarker for treatment prediction.\n                  <\/jats:p>","DOI":"10.1155\/mi\/5035877","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:21:18Z","timestamp":1761916878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of\n                    <i>Fusobacterium nucleatum<\/i>\n                    on Tumor Necrosis Factor Alpha Therapy in Ulcerative Colitis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0972-3259","authenticated-orcid":false,"given":"Bilge","family":"\u015eeny\u00fcz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-2450","authenticated-orcid":false,"given":"Nalan G\u00fcl\u015fen","family":"\u00dcnal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-4350","authenticated-orcid":false,"given":"Ba\u015fak Do\u011fanav\u015fargil","family":"Yakut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-0509","authenticated-orcid":false,"given":"Ata\u00e7","family":"Uzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-3237","authenticated-orcid":false,"given":"Cumhur","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-150X","authenticated-orcid":false,"given":"Sunde Y\u0131lmaz","family":"S\u00fcsl\u00fcer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/540S97a"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3350-9"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.91"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1744-3"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(08)60530-7"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV.IMMUNOL.23.021704.115839"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2010.04.004"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2007.05.006"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-017-0813-5"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030126"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.08.078"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179139"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706625104"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0368-4"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040944"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab020"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01393.x"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0205"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15992"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.07.012"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050516"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20520"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.06.024"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.594806"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbab029"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12909"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.8.913"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05118-11"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/mi\/5035877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/mi\/5035877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/mi\/5035877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:18:16Z","timestamp":1773008296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/mi\/5035877"}},"subtitle":[],"editor":[{"given":"Luigi","family":"Cari","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/mi\/5035877"],"URL":"https:\/\/doi.org\/10.1155\/mi\/5035877","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5035877"}}