{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:38:23Z","timestamp":1773013103989,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":191,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Low\u2010density granulocytes (LDGs), a unique subset of neutrophils, have been shown in previous studies to exhibit distinct biological functions in immune\u2010inflammatory diseases. However, their role in acute pancreatitis (AP) remains unclear.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To investigate the association between peripheral blood LDGs levels and clinical severity in patients with AP.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This cross\u2010sectional study analyzed peripheral LDGs levels in 41 mild AP (MAP) patients, 40 moderate\u2010to\u2010severe AP (SAP) patients, and 41 healthy controls (HC). LDGs were measured within 24\u2009h of admission. Statistical analysis, including Kruskal\u2013Wallis tests and logistic regression, assessed LDGs\u2019 association with clinical characteristics and AP severity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    LDGs levels were significantly higher in moderate\u2010to\u2010SAP compared to MAP and HC (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Elevated LDGs levels correlated positively with white blood cell count (WBC), glucose (GLU), neutrophil\u2010to\u2010lymphocyte ratio, Acute Physiology and Chronic Health Evaluation II (APACHE II), and Bedside Index for Severity in Acute Pancreatitis (BISAP) scores (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Logistic regression identified LDGs as an independent risk factor for moderate\u2010to\u2010SAP. Receiver operating characteristic (ROC) analysis revealed high predictive accuracy, the area under the curve (AUC\u2009=\u20090.967) at a 2.96% cutoff, with 95.0% sensitivity and 90.2% specificity. The follow\u2010up indicated that patients with LDGs\u2009&gt;\u20092.96% had a higher risk of recurrence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Elevated peripheral LDGs levels in AP patients are associated with disease activity.\n                  <\/jats:p>","DOI":"10.1155\/mi\/5275081","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T07:34:46Z","timestamp":1752219286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Significance of Low\u2010Density Granulocytes in Acute 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