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Cardiac function, reactive oxygen species (ROS), inflammation, and the SIRT1\/HMGB1 pathway were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PPF combined with SAA synergistically attenuated cardiac inflammation, pyroptosis, and dysfunction, accompanied by SIRT1 upregulation and HMGB1 downregulation. Notably, low\u2010dose coadministration of PPF (12.5\u2009\u00b5M) and SAA (12.5\u2009\u00b5M) achieved protection comparable to high\u2010dose PPF (25\u2009\u00b5M), significantly reducing ROS and pyroptosis markers. These protective effects were reversed by SIRT1 inhibition or silencing but enhanced by HMGB1 inhibition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PPF and SAA synergistically inhibit LPS\u2010induced myocardial pyroptosis under hyperglycemia by activating the SIRT1\/HMGB1 pathway. This combination offers a potential strategy to enhance cardioprotection while minimizing anesthetic dosage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/mi\/6298056","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:05:44Z","timestamp":1783415144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Propofol and Salvianolic Acid a Synergistically Attenuate LPS\u2010Induced Myocardial Pyroptosis in Diabetic Mice via the SIRT1\/HMGB1 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