{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:04:01Z","timestamp":1784127841251,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":306,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974250"],"award-info":[{"award-number":["81974250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Gout is a common autoinflammatory disease that clinically manifests as recurrent joint redness, swelling, and pain, but the molecular mechanism of recurrent gouty inflammation remains unclear. Circular RNAs (circRNAs) might exert their function by regulating autophagy. Our previous studies revealed that autophagy\u2010related genes (ATGs) are differentially expressed in patients with acute gout. The aim of this study was to investigate the molecular mechanism by which circ_0058051 regulates autophagy as a competitive endogenous RNA (ceRNA) in recurrent gouty inflammation. Real\u2010time quantitative PCR was used to measure the expression of circ_0058051, miR\u2010129\u20105p, ATG7, LC3, and IL\u20101\u03b2. Western blotting was used to assess the protein levels of ATG7, LC3, and IL\u20101\u03b2. Enzyme\u2010linked immunosorbent assay (ELISA) was used to measure the IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 levels. A dual\u2010luciferase reporter assay was used to confirm the interaction between circ_0058051, miR\u2010129\u20105p, and ATG7. The gout group expressed significantly more circ_0058051 and ATG7 and significantly less miR\u2010129\u20105p than the HC group. In the 20 paired cases, compared with stable gout cases, the expression of circ_0058051 and ATG7 was significantly greater during a gout attack and even greater in patients with gout recurrence. The significant decrease in miR\u2010129\u20105p expression was more pronounced in patients with gout recurrence. In the simulation model of gout recurrence in the peripheral blood of intercritical gout patients stimulated with MSU, circ_0058051 peaked 2\u2009h after MSU stimulation, ATG7 peaked 1\u2009h after MSU stimulation, and miR\u2010129\u20105p expression was lowest 1\u2009h after MSU stimulation. In addition, the expression levels of circ_0058051, ATG7, IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20106, and LC3 significantly increased after THP\u20101 macrophages were treated with MSU, and the expression of miR\u2010129\u20105p significantly decreased. In MSU\u2010stimulated THP\u20101 macrophages, circ_0058051 sponges miR\u2010129\u20105p to promote the expression of the miR\u2010129\u20105p target gene ATG7, leading to acute gout attack. Our findings suggest that circ_0058051 is involved in the recurrence of acute gout by targeting miR\u2010129\u20105p to regulate ATG7\u2010mediated autophagy.<\/jats:p>","DOI":"10.1155\/mi\/6645479","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:34:00Z","timestamp":1762202040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circ_0058051 Targeted miR\u2010129\u20105P Regulates Autophagy\u2010Related Gene ATG7 to Promote the Inflammation of 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