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However, the causal role of circulating inflammatory proteins in HT remains uncertain. To investigate this, we conducted a bidirectional Mendelian randomization (MR) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genetic data for 91 inflammatory proteins and HT were sourced from publicly available GWAS databases. The PhenoScanner database was then searched for pleiotropic SNPs associated with potential confounders. Inverse variance weighted (IVW) analysis was used as the primary analysis, simultaneously supplemented by five sensitivity analyses to strengthen the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results revealed that, after false discovery rate (FDR) correction, interleukin (IL)\u201012p40 was causally associated with increased risk of HT (OR [95% CI]\u2009=\u20091.295 [1.172, 1.431],\n                      <jats:italic>p<\/jats:italic>\n                      = 3.66 \u00d7 10\n                      <jats:sup>\u22127<\/jats:sup>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u2009=\u20093.33\u00d710\n                      <jats:sup>\u22125<\/jats:sup>\n                      ). Conversely, none of the inflammatory proteins was a consequence of HT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that IL\u201012p40 is probably one of the factors correlated with HT etiology, contributing to a better understanding of the pathogenesis of HT and underscoring the potential for therapeutic interventions targeting inflammatory proteins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/mi\/6651720","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:26:06Z","timestamp":1788848766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Causal Links Between 91 Circulating Inflammatory Proteins and Hashimoto\u2019s Thyroiditis: A Bidirectional Mendelian Randomization 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