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A\n                    <jats:italic>F. prausnitzii<\/jats:italic>\n                    \u2010colonized C57BL\/6 mice model was tested by a rectal enema with 1\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    bacteria\/day for 3 days. The 5% DSS was added to drinking water for 3 days to induce colitis and diarrhea in experimental mice. The clinical, cytological, and histological severities were compared between groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The\n                    <jats:italic>F. prausnitzii<\/jats:italic>\n                    \u2010colonized mice model was successfully established via rectal enema with the property of transfer to offspring. DSS treatment altered gut microbiota and significantly attenuated the abundance of\n                    <jats:italic>F. prausnitzii<\/jats:italic>\n                    in colonized mice. Mice with\n                    <jats:italic>F. prausnitzii<\/jats:italic>\n                    colonization had significantly improved weight loss, anal bleeding, stool consistency, cecum weight, colon length, and serum amyloid A (SAA) level than those without after DSS treatment. Furthermore, the\n                    <jats:italic>F. prausnitzii<\/jats:italic>\n                    \u2010colonized mice significantly reduced the transcription levels of TNF\u2010\u03b1, INF\u2010\u03b3 and IL\u201018, and epithelial damage and PMN infiltration in the lamina propria and had better preservation of goblet cells than the control group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    We have successfully established a mouse model colonized with\n                    <jats:italic>F. prausnitzii<\/jats:italic>\n                    via rectal enema administration and showed colonization of\n                    <jats:italic>F. prausnitzii<\/jats:italic>\n                    in the gut has a protective effect against DSS\u2010induced colitis.\n                  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