{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T21:30:33Z","timestamp":1768599033288,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["W0155"],"award-info":[{"award-number":["W0155"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12004059"],"award-info":[{"award-number":["12004059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of low intensity pulsed ultrasound (LIPUS) combined with imipenem (IMI) on inflammatory responses and organ protection in septic rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study involved 230 Sprague\u2013Dawley (SD) rats, with 80 used for survival analysis and 150 for sampling over 72\u2009h. Histological examination (hematoxylin and eosin [H&amp;E] staining) and transmission electron microscopy (TEM) revealed that LIPUS combined with IMI significantly alleviated spleen tissue damage and reduced mitochondrial edema. Key inflammatory cytokines, such as interleukin\u20101 beta (IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ), tumor necrosis factor\u2010alpha (TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ), and IL\u20106 were significantly decreased, while IL\u201010 levels increased in the LIPUS\u2009+\u2009IMI group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The combined treatment also reduced the expression of cytokines, such as IL\u20101 receptor (IL\u20101R), nuclear factor kappa B p65 (NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B p65), transforming growth factor\u2010beta (TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ), and high mobility group protein box 1 (HMGB1), indicating a reduction in inflammation (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Innovation<\/jats:title>\n                    <jats:p>\n                      This study presents a novel approach by integrating LIPUS with IMI, providing a noninvasive and effective strategy to mitigate cytokine storms, optimize antibiotic use, and reduce organ damage in sepsis. The protective effects observed are primarily attributed to the inhibition of the IL\u20101R\/NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B signaling pathway, which significantly improves survival outcomes in septic rats. This combined therapy has potential for enhancing sepsis treatment protocols.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/mi\/7323319","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:23:16Z","timestamp":1768562596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Alleviation of Inflammatory Cytokine Storms in Sepsis Rats by Low\u2010Intensity Pulsed Ultrasound and 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