{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:52:23Z","timestamp":1793731943169,"version":"4.6.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012829","name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["YN2024GZRPY030"],"award-info":[{"award-number":["YN2024GZRPY030"]}],"id":[{"id":"10.13039\/100012829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341233"],"award-info":[{"award-number":["82341233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021B005"],"award-info":[{"award-number":["CI2021B005"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    This study aims to reveal the potential molecular mechanisms of modified Gegen Qinlian decoction (MGQD) in relieving ulcerative colitis (UC).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    C57BL\/6J mice were used to establish experimental colitis via dextran sodium sulfate (DSS). Body weight, disease activity index (DAI), spleen weight, colon length, and histopathologic features were measured to evaluate the therapeutic effects of MGQD on mice with UC. The ELISA kits were employed to assess the concentrations of interleukin (IL)\u20106, IL\u20101\u03b2, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), glutathione (GSH), reactive oxygen species (ROS), and malondialdehyde (MDA). Western blot analyses were used to assess the levels of I\u03baB\u03b1, p65, p\u2010I\u03baB\u03b1, p\u2010p65, HO\u20101, and Nrf2. Moreover, the protein levels of Nrf2 and p\u2010p65 were assessed by immunofluorescence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Colitis\u2010related symptoms in mice were significantly alleviated by MGQD. Moreover, MGQD inhibited the levels of TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, MDA, and ROS and increased the level of GSH in mice with UC. Mechanistically, MGQD prevented the activation of the NF\u2010\u03baB pathway and concomitantly promoted the activation of the Nrf2\/HO\u20101 pathway.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    MGQD alleviated UC by suppressing inflammation and oxidative stress via the modulation of NF\u2010\u03baB and Nrf2\/HO\u20101 pathways, suggesting that MGQD may be a candidate therapy for UC.\n                  <\/jats:p>","DOI":"10.1155\/mi\/7468297","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:05:44Z","timestamp":1737011144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modified Gegen Qinlian Decoction Ameliorates DSS\u2010Induced Colitis in Mice via the Modulation of NF\u2010\n                    <i>\u03ba<\/i>\n                    B and Nrf2\/HO\u20101 Pathways"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-0564","authenticated-orcid":false,"given":"Jinke","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3143-5651","authenticated-orcid":false,"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-9636","authenticated-orcid":false,"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7144-9273","authenticated-orcid":false,"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8274-9434","authenticated-orcid":false,"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-7905","authenticated-orcid":false,"given":"Fengyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-3895","authenticated-orcid":false,"given":"Xudong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.186"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.03.002"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0415-0"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00966-2"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/493012"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820927550"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.668418"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7942845"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.756978"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154660"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/6802701"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.713"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.01.023"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.103017"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00291.x"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-005-0208-4"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200008000-00007"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.631809"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6817156"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105243"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122345"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1457010"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3562"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22943"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13081012"}],"container-title":["Mediators 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