{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:12:30Z","timestamp":1778141550332,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":126,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022-JYJ-153"],"award-info":[{"award-number":["2022-JYJ-153"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive impairment is a common feature of neurodegenerative diseases, in which sustained neuroinflammation critically contributes to neuronal dysfunction and memory decline. As a representative condition, Alzheimer\u2019s disease (AD) provides key insights into inflammation\u2010associated cognitive impairment. However, current anti\u2010inflammatory interventions exhibit limited efficacy and potential adverse effects, highlighting the need for safer strategies targeting neuroinflammation\u2010related cognitive dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Guided by the concept of food\u2013medicine homology, this study aimed to elucidate the molecular mechanisms by which\n                      <jats:italic>Ziziphus jujuba<\/jats:italic>\n                      alleviates cognitive impairment associated with neuroinflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      AD\u2010relevant targets associated with cognitive dysfunction were obtained from Gene Expression Omnibus (GEO) and GeneCards, and active compounds of\n                      <jats:italic>Z. jujuba<\/jats:italic>\n                      were retrieved from traditional Chinese medicine systems pharmacology (TCMSP). Shared targets were prioritized using least absolute shrinkage and selection operator (LASSO), random forest (RF), and support vector machine (SVM) algorithms. The diagnostic value of the core target was evaluated by receiver operating characteristic (ROC) analysis and a nomogram model with calibration and decision curve analysis (DCA). Functional enrichment, localization analyses, and molecular docking were performed. Experimental validation was conducted in a scopolamine\u2010induced cognitive impairment mouse model using the Morris water maze (MWM), histopathology, and western blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PTGS2 was identified as a key inflammatory target associated with neuroinflammation\u2010related cognitive impairment and was enriched in the NOD\u2010like receptor (NLR) signaling pathway. ROC and nomogram analyses indicated good diagnostic and predictive performance (area under the curve [AUC]\u2009&gt;\u20090.7). PTGS2 was localized on chromosome 1 and showed relatively high expression in the cerebral cortex.\n                      <jats:italic>Z. jujuba<\/jats:italic>\n                      compounds exhibited strong binding to PTGS2 (\u0394G\u2009\u2264\u2009\u22128.0 kcal\/mol). In vivo,\n                      <jats:italic>Z. jujuba<\/jats:italic>\n                      improved cognitive performance, alleviated hippocampal injury, and downregulated PTGS2 and related inflammatory signaling pathways, including NLRP3\/NF\u2010\u03baB\/MAPK and interleukin (IL)\u20101\u03b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that\n                      <jats:italic>Z. jujuba<\/jats:italic>\n                      ameliorates neuroinflammation\u2010related cognitive dysfunction primarily by suppressing PTGS2\u2010centered inflammatory signaling. Integrating computational analyses and in vivo validation in scopolamine\u2010induced mice, our findings support\n                      <jats:italic>Z. jujuba<\/jats:italic>\n                      as a safe multitarget intervention for inflammation\u2010associated cognitive impairment and highlight the potential of food\u2013medicine homology in neuroinflammatory cognitive disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/mi\/8871660","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:31:58Z","timestamp":1778139118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Ziziphus jujuba<\/i>\n                    Mill. Suspension Ameliorates Scopolamine\u2010Induced Cognitive Impairment via PTGS2\u2010Centered Neuroinflammatory 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