{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:16:53Z","timestamp":1788952613089,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":251,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ5243"],"award-info":[{"award-number":["2024JJ5243"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ80655"],"award-info":[{"award-number":["2025JJ80655"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis\u2010induced acute lung injury (SI\u2010ALI) represents a life\u2010threatening condition driven by dysregulated immune responses and redox imbalance. Demethoxycurcumin (DMC), a bioactive analog of curcumin, exhibits marked anti\u2010inflammatory and free radical\u2010scavenging capacities. Despite its potential, the precise molecular pathways through which DMC mitigates SI\u2010ALI pathogenesis have yet to be fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SI\u2010ALI was induced in mice through lipopolysaccharide (LPS) administration. Lung injury was assessed by histopathological analysis and measurement of wet\u2010to\u2010dry (W\/D) weight ratios. Oxidative stress markers were quantified using ELISA, and inflammatory cytokine mRNA levels were analyzed by RT\u2010PCR. Ferroptosis\u2010related proteins and Nrf2 pathway activation were evaluated through Western blotting and immunofluorescence. Mitochondrial ultrastructure was examined via transmission electron microscopy (TEM). The involvement of the Nrf2 pathway was further confirmed by using the Nrf2 inhibitor ML385.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DMC treatment significantly alleviated lung injury in a dose\u2010dependent manner, improving histopathology and reducing W\/D weight ratios. It attenuated inflammation by suppressing IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2 expression and restored oxidative balance by enhancing glutathione (GSH) levels while decreasing malondialdehyde (MDA). Moreover, DMC upregulated glutathione peroxidase 4 (GPX4) and SLC7A11, downregulated cyclooxygenase\u20102 (COX2) and ACSL4, reduced nonheme iron and 4\u2010hydroxynonenal (4\u2010HNE) production, and improved mitochondrial morphology, collectively demonstrating its inhibitory effects on ferroptosis. Nrf2 inhibition partially reversed these protective effects, underscoring the central role of the Nrf2 pathway in DMC\u2019s mechanism of action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DMC ameliorates SI\u2010ALI by mitigating inflammation and ferroptosis through Nrf2 pathway activation, suggesting a potential therapeutic strategy for SI\u2010ALI treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/mi\/9154680","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:46:28Z","timestamp":1788950788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Demethoxycurcumin Alleviates Lipopolysaccharide\u2010Induced Acute Lung Injury via Nrf2\u2010Mediated Anti\u2010Inflammation and Ferroptosis 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