{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:09:29Z","timestamp":1793329769043,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":217,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["313894\/2023-0"],"award-info":[{"award-number":["313894\/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02831-23"],"award-info":[{"award-number":["APQ-02831-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Activation of the NLRP3 inflammasome and its downstream cytokines IL\u20101\u03b2 and IL\u201018 has been increasingly associated with the inflammatory mechanisms underlying diabetic nephropathy (DN), the leading cause of chronic kidney disease and end\u2010stage renal disease worldwide. This study investigated the expression of these inflammatory mediators in renal tissue from patients with DN. Eighty renal biopsies from adult patients (\u226518 years) with a histopathological diagnosis of DN and 22 control samples obtained from autopsies were analyzed. NLRP3, IL\u20101\u03b2, and IL\u201018 expression was assessed by immunohistochemistry, and semi\u2010quantitative analysis was performed to determine the proportion of immunostained cells in the glomerular and interstitial compartments. A significant increase in immunostaining for all three mediators was observed in mesangial cells, podocytes, endothelial cells, and the interstitium of DN samples compared with controls (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Positive and significant correlations were found between NLRP3 and IL\u20101\u03b2 in endothelial cells (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001; rS\u2009=\u20090.4720) and in the interstitium (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0230; rS\u2009=\u20090.2540), as well as between NLRP3 and IL\u201018 in podocytes (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0055; rS\u2009=\u20090.3074). Moreover, interstitial expression of NLRP3 and IL\u20101\u03b2 correlated positively with serum creatinine levels (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0015; rS\u2009=\u20090.3708; and\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0029; rS\u2009=\u20090.3480, respectively), suggesting an association between inflammasome\u2010mediated inflammation and renal dysfunction. Collectively, these findings indicate that the NLRP3\/IL\u20101\u03b2\/IL\u201018 axis plays a central role in glomerular and interstitial injury in DN, supporting its potential as a prognostic biomarker and a promising therapeutic target for disease modulation.\n                  <\/jats:p>","DOI":"10.1155\/mi\/9937801","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:53:02Z","timestamp":1786024382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tissue Expression of NLRP3, IL\u20101\u03b2, and IL\u201018 in Glomerular and Interstitial Inflammation Associated With Diabetic Nephropathy"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6085-5965","authenticated-orcid":false,"given":"Bruna de Freitas","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-4014","authenticated-orcid":false,"given":"Liliane Silvano","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0615-1446","authenticated-orcid":false,"given":"Crislaine Aparecida da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-0241","authenticated-orcid":false,"given":"Laura Penna","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-3808","authenticated-orcid":false,"given":"Ra\u00edssa Bernardes da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2523-2097","authenticated-orcid":false,"given":"Marlene Ant\u00f4nia dos","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-9142","authenticated-orcid":false,"given":"Rafael Obata","family":"Trevisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7926-5199","authenticated-orcid":false,"given":"Bruna Cunha","family":"Zaidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-7788","authenticated-orcid":false,"given":"Juliana Reis","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"Nefropatia Diab\u00e9tica: Uma Vis\u00e3o Geral. Nefropatia Diab\u00e9tica","author":"Sagoo M. K.","year":"2020"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1497449"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113798"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2435-8264"},{"key":"e_1_2_10_5_2","first-page":"80","article-title":"Nefropatia Diab\u00e9tica","volume":"16","author":"Bou\u00e7a B.","year":"2021","journal-title":"Revista Portuguesa de Diabetes"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-01960-0"},{"key":"e_1_2_10_7_2","doi-asserted-by":"crossref","DOI":"10.56083\/RCV4N12-166","article-title":"Perfil Epidemiol\u00f3gico Dos Pacientes Com Diabetes Mellitus, Submetidos a Bi\u00f3psia Renal Em Um Hospital Terci\u00e1rio","volume":"4","author":"Bessa F. X. 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