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Characterized by intricate clonality and dysregulated inflammation, PMF leads to heightened morbidity, mortality, and an elevated risk of leukemic transformation. The inflammatory state in PMF results from the convoluted interplay of excessive inflammatory mediator production, heightened oxidative stress, and immune system dysregulation. These factors fuel the expansion of the myeloproliferative clone, accelerate disease progression toward leukemia, and contribute to bone marrow (BM) fibrosis by acting on BM stromal cells. This review comprehensively integrates recent research findings, especially those from single\u2010cell RNA sequencing, to identify the sources and regulatory mechanisms of inflammatory mediator overproduction, oxidative stress, and immune system dysregulation in PMF. It also elaborates on the key cytokines and pathways governing the interaction between malignant hematopoietic cells and BM stromal cells. By providing a comprehensive perspective, this review aims to guide future research on cellular and molecular targets within the hematopoietic niche and explore therapeutic approaches targeting immune cells and cytokines for PMF treatment. The potential of anti\u2010inflammatory therapies in the clinical management of PMF is also highlighted.<\/jats:p>","DOI":"10.1155\/mi\/9967975","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T11:50:21Z","timestamp":1762948221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chronic Inflammation in Primary Myelofibrosis: In\u2010Depth Insights Into Pathogenesis and Promising Anti\u2010Inflammatory Therapeutic 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